(2R,3aR,4S,7R,7aS)-2-Methyl-2-m-tolyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one

Base Information

• Chemical Name: (2R,3aR,4S,7R,7aS)-2-Methyl-2-m-tolyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one
• CAS No.: 139618-38-5
• Molecular Formula: C₁₈H₂₀O
• Molecular Weight: 252.356

Synonyms:(2R,3aR,4S,7R,7aS)-2-Methyl-2-m-tolyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one

Chemical Property of (2R,3aR,4S,7R,7aS)-2-Methyl-2-m-tolyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one

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Technology Process of (2R,3aR,4S,7R,7aS)-2-Methyl-2-m-tolyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one

There total 2 articles about (2R,3aR,4S,7R,7aS)-2-Methyl-2-m-tolyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C18H21NO (139618-37-4) → (2R,3aR,4S,7R,7aS)-2-Methyl-2-m-tolyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one (139618-38-5)

Guidance literature:

With hypophosphorous acid; sodium nitrite; at 0 ℃;

DOI:10.1016/S0040-4039(00)74123-2

Reference yield:

(3aR,4S,7R,7aS)-2-Methyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one (139685-71-5) → (2R,3aR,4S,7R,7aS)-2-Methyl-2-m-tolyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one (139618-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / pyridine / H₂O / Heating

2: 70 percent / NaNO₂, H₃PO₂ / 0 °C

With pyridine; hypophosphorous acid; sodium nitrite; In water;

DOI:10.1016/S0040-4039(00)74123-2

Reference yield: 71.0%

(2R,3aR,4S,7R,7aS)-2-Methyl-2-m-tolyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one (139618-38-5) → (R)-5-Methyl-5-m-tolyl-cyclopent-2-enone (139642-71-0)

Guidance literature:

In various solvent(s); Heating;

DOI:10.1016/S0040-4039(00)74123-2

upstream raw materials:

C₁₈H₂₁NO

(3aR,4S,7R,7aS)-2-Methyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one

Downstream raw materials:

(R)-5-Methyl-5-m-tolyl-cyclopent-2-enone

(R)-1,5-Dimethyl-5-m-tolyl-cyclopent-2-enol

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