(S)-4-benzyl-3-{(R)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-5-hexenoyl}-2-oxazolidinone

Base Information

Chemical Name:(S)-4-benzyl-3-{(R)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-5-hexenoyl}-2-oxazolidinone
CAS No.:934219-67-7
Molecular Formula:C₃₄H₄₉NO₆Si
Molecular Weight:595.852
Hs Code.:

Synonyms:(S)-4-benzyl-3-{(R)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-5-hexenoyl}-2-oxazolidinone

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Chemical Property of (S)-4-benzyl-3-{(R)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-5-hexenoyl}-2-oxazolidinone

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Technology Process of (S)-4-benzyl-3-{(R)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-5-hexenoyl}-2-oxazolidinone

There total 5 articles about (S)-4-benzyl-3-{(R)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-5-hexenoyl}-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 934219-66-6
(S)-4-benzyl-3-{(R)-2-[(S)-(hydroxy)(3,4-dimethoxyphenyl)methyl]-5-hexenoyl}-2-oxazolidinone

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 934219-67-7
(S)-4-benzyl-3-{(R)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-5-hexenoyl}-2-oxazolidinone

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/np060461j

Reference yield:

: 1577-22-6
5-hexenoic acid

: 934219-67-7
(S)-4-benzyl-3-{(R)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-5-hexenoyl}-2-oxazolidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N / tetrahydrofuran / 1 h / 0 °C

2.1: 15.6 g / tetrahydrofuran / 1 h / 0 °C

3.1: Et₃N; chlorotrimethylsilane; MgCl₂ / ethyl acetate / 16 h / 20 °C

3.2: 93 percent / TFA / methanol; ethyl acetate / 0.5 h / 20 °C

4.1: 91 percent / 2,6-litidine / CH₂Cl₂ / 1 h / 20 °C

With 2,6-dimethylpyridine; chloro-trimethyl-silane; triethylamine; magnesium chloride; In tetrahydrofuran; dichloromethane; ethyl acetate; 3.1: Evans' aldol reaction;
DOI:10.1021/np060461j

Reference yield:

: C₁₁H₁₈O₃

: 934219-67-7
(S)-4-benzyl-3-{(R)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-5-hexenoyl}-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 15.6 g / tetrahydrofuran / 1 h / 0 °C

2.1: Et₃N; chlorotrimethylsilane; MgCl₂ / ethyl acetate / 16 h / 20 °C

2.2: 93 percent / TFA / methanol; ethyl acetate / 0.5 h / 20 °C

3.1: 91 percent / 2,6-litidine / CH₂Cl₂ / 1 h / 20 °C

With 2,6-dimethylpyridine; chloro-trimethyl-silane; triethylamine; magnesium chloride; In tetrahydrofuran; dichloromethane; ethyl acetate; 2.1: Evans' aldol reaction;
DOI:10.1021/np060461j