3-ethyl-5-methoxy-7-methylsulfanyl-1-phenyl-4-thioxo-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

Base Information

Chemical Name:3-ethyl-5-methoxy-7-methylsulfanyl-1-phenyl-4-thioxo-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
CAS No.:1636170-01-8
Molecular Formula:C₁₆H₁₆N₄O₂S₂
Molecular Weight:360.461
Hs Code.:

Synonyms:3-ethyl-5-methoxy-7-methylsulfanyl-1-phenyl-4-thioxo-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

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Chemical Property of 3-ethyl-5-methoxy-7-methylsulfanyl-1-phenyl-4-thioxo-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

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Technology Process of 3-ethyl-5-methoxy-7-methylsulfanyl-1-phenyl-4-thioxo-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

There total 3 articles about 3-ethyl-5-methoxy-7-methylsulfanyl-1-phenyl-4-thioxo-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1636169-83-9
N-butyl-4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine-5-carbothioamide

: 103-71-9
phenyl isocyanate

: 1636170-01-8
3-ethyl-5-methoxy-7-methylsulfanyl-1-phenyl-4-thioxo-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

Guidance literature:: N-butyl-4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine-5-carbothioamide; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃;

phenyl isocyanate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h;
DOI:10.3987/COM-14-13038

Reference yield:

: 89466-42-2
4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine

: 1636170-01-8
3-ethyl-5-methoxy-7-methylsulfanyl-1-phenyl-4-thioxo-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: 0.08 h / -78 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 0 °C

2.2: 0.25 h / 0 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.3987/COM-14-13038

Reference yield:

: 6299-25-8
4,6-Dichloro-2-(methylthio)pyrimidine

: 1636170-01-8
3-ethyl-5-methoxy-7-methylsulfanyl-1-phenyl-4-thioxo-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

2.2: 0.08 h / -78 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 0 °C

3.2: 0.25 h / 0 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.3987/COM-14-13038