acetic acid 1-[2-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4-cyano-butyl]-prop-2-ynyl ester

Base Information

Chemical Name:acetic acid 1-[2-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4-cyano-butyl]-prop-2-ynyl ester
CAS No.:191787-59-4
Molecular Formula:C₂₃H₃₃NO₄Si
Molecular Weight:415.605
Hs Code.:

acetic acid 1-[2-benzyloxy-3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-4-cyano-butyl]-prop-2-ynyl ester

Synonyms:acetic acid 1-[2-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4-cyano-butyl]-prop-2-ynyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of acetic acid 1-[2-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4-cyano-butyl]-prop-2-ynyl ester

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Technology Process of acetic acid 1-[2-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4-cyano-butyl]-prop-2-ynyl ester

There total 3 articles about acetic acid 1-[2-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4-cyano-butyl]-prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 108-24-7
acetic anhydride

: 186809-15-4
(3S,4R,6R)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-oct-7-ynenitrile

: 191787-59-4
acetic acid 1-[2-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4-cyano-butyl]-prop-2-ynyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ja970839n

Reference yield:

: (3S,4R)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-oct-7-ynenitrile

: 191787-59-4
acetic acid 1-[2-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4-cyano-butyl]-prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / Jones reagent / acetone / 0 °C

2: LiAlH₄; Darvon alcohol / -78 °C

3: 94 percent / DMAP; triethylamine / CH₂Cl₂ / 0 - 20 °C

With dmap; lithium aluminium tetrahydride; jones reagent; Darvon alcohol; triethylamine; In dichloromethane; acetone; 1: Oxidation / 2: Reduction / 3: Acetylation;
DOI:10.1021/ja970839n

Reference yield:

: 191787-58-3
(3S,4R)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-oxo-oct-7-ynenitrile

: 191787-59-4
acetic acid 1-[2-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4-cyano-butyl]-prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄; Darvon alcohol / -78 °C

2: 94 percent / DMAP; triethylamine / CH₂Cl₂ / 0 - 20 °C

With dmap; lithium aluminium tetrahydride; Darvon alcohol; triethylamine; In dichloromethane; 1: Reduction / 2: Acetylation;
DOI:10.1021/ja970839n