3-(1-benzyl-3-methylpyrrolidin-3-yl)-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:3-(1-benzyl-3-methylpyrrolidin-3-yl)-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:1404062-75-4
Molecular Formula:C₂₈H₃₁N₃O₆
Molecular Weight:505.571
Hs Code.:

Synonyms:3-(1-benzyl-3-methylpyrrolidin-3-yl)-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of 3-(1-benzyl-3-methylpyrrolidin-3-yl)-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of 3-(1-benzyl-3-methylpyrrolidin-3-yl)-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

There total 6 articles about 3-(1-benzyl-3-methylpyrrolidin-3-yl)-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88712-56-5,125185-92-4
1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid chloride

: 96567-93-0
1-benzyl-3-methylpyrrolidin-3-ol

: 1404062-75-4
3-(1-benzyl-3-methylpyrrolidin-3-yl)-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: In dichloromethane; at -25 - 20 ℃; for 12h;

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 1404062-75-4
3-(1-benzyl-3-methylpyrrolidin-3-yl)-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium bicarbonate / ethanol; water / 55 - 60 °C / Reflux

2: methanol; water; sodium hydroxide / 6 h / 70 °C

3: thionyl chloride / dichloromethane / -25 °C / Cooling with ice

4: dichloromethane / 12 h / -25 - 20 °C

With methanol; thionyl chloride; water; ammonium bicarbonate; sodium hydroxide; In ethanol; dichloromethane; water;

Reference yield:

: 21881-77-6
m-nifedipine

: 1404062-75-4
3-(1-benzyl-3-methylpyrrolidin-3-yl)-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; water; sodium hydroxide / 6 h / 70 °C

2: thionyl chloride / dichloromethane / -25 °C / Cooling with ice

3: dichloromethane / 12 h / -25 - 20 °C

With methanol; thionyl chloride; water; sodium hydroxide; In dichloromethane;