Cyanamide, (3,4-dihydro-3-(1-(2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl)-4-piperidinyl)-2-quinazolinyl)-

Base Information

Chemical Name:Cyanamide, (3,4-dihydro-3-(1-(2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl)-4-piperidinyl)-2-quinazolinyl)-
CAS No.:79106-73-3
Molecular Formula:C25H31N5O4
Molecular Weight:465.5447
Hs Code.:
DSSTox Substance ID:DTXSID001000269

Synonyms:79106-73-3;Cyanamide, (3,4-dihydro-3-(1-(2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl)-4-piperidinyl)-2-quinazolinyl)-;DTXSID001000269;LS-55763;[3-{1-[2-Hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]piperidin-4-yl}-3,4-dihydroquinazolin-2(1H)-ylidene]cyanamide

Suppliers and Price of Cyanamide, (3,4-dihydro-3-(1-(2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl)-4-piperidinyl)-2-quinazolinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Cyanamide, (3,4-dihydro-3-(1-(2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl)-4-piperidinyl)-2-quinazolinyl)-

Chemical Property:

Vapor Pressure:5.58E-17mmHg at 25°C
Boiling Point:634.7°Cat760mmHg
Flash Point:337.6°C
Density:1.28g/cm³
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:465.23760449
Heavy Atom Count:34
Complexity:720

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C(CN2CCC(CC2)N3CC4=CC=CC=C4N=C3NC#N)O

Technology Process of Cyanamide, (3,4-dihydro-3-(1-(2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl)-4-piperidinyl)-2-quinazolinyl)-

There total 8 articles about Cyanamide, (3,4-dihydro-3-(1-(2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl)-4-piperidinyl)-2-quinazolinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 79106-67-5
3-{1-[2-Oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide

: 79106-73-3
3-{1-[2-Hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 1.5h; Ambient temperature;
DOI:10.1002/jhet.5570200315

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 79106-73-3
3-{1-[2-Hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide

Guidance literature:: Multi-step reaction with 6 steps

1: 2) NaBH₄ / 1) methanol, 20 deg C, 1 h; 2) 1 h

2: 78 percent / H₂ / Pd/C / ethanol / 10 h / 20 °C / 2585.7 Torr

3: 43 percent / DBU / dioxane / 10 h / 20 °C

4: 94 percent / HCl / ethyl acetate / Ambient temperature

5: 53 percent / triethylamine / methanol / 20 °C

6: 77 percent / NaBH₄ / ethanol / 1.5 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; ethyl acetate;
DOI:10.1002/jhet.5570200315

Reference yield:

: 87120-79-4
tert-butyl 4-((2-nitrobenzyl)amino)piperidine-1-carboxylate

: 79106-73-3
3-{1-[2-Hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-piperidin-4-yl}-3,4-dihydro-quinazolin-2-yl-cyanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / H₂ / Pd/C / ethanol / 10 h / 20 °C / 2585.7 Torr

2: 43 percent / DBU / dioxane / 10 h / 20 °C

3: 94 percent / HCl / ethyl acetate / Ambient temperature

4: 53 percent / triethylamine / methanol / 20 °C

5: 77 percent / NaBH₄ / ethanol / 1.5 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; ethyl acetate;
DOI:10.1002/jhet.5570200315