2-[4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-fluorophenyl]-acetohydrazide

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Chemical Name:2-[4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-fluorophenyl]-acetohydrazide
CAS No.:1437779-19-5
Molecular Formula:C₂₂H₂₇ClFN₅O₂
Molecular Weight:447.94
Hs Code.:

Synonyms:2-[4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-fluorophenyl]-acetohydrazide

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Chemical Property of 2-[4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-fluorophenyl]-acetohydrazide

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Technology Process of 2-[4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-fluorophenyl]-acetohydrazide

There total 5 articles about 2-[4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-fluorophenyl]-acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68886-07-7
(2-fluoro-4-hydroxylphenyl)acetic acid

: 1437779-19-5
2-[4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-fluorophenyl]-acetohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / Reflux

2.1: di-tert-butyl-diazodicarboxylate / dichloromethane / 3 h / 20 °C

3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

3.2: pH 4

4.1: triethylamine; methyl chloroformate / tetrahydrofuran / 0.5 h / -10 °C

4.2: 20 °C

With di-tert-butyl-diazodicarboxylate; sulfuric acid; water; triethylamine; methyl chloroformate; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1437778-95-4
[4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-fluorophenyl]acetic acid

: 1437779-19-5
2-[4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-fluorophenyl]-acetohydrazide

Guidance literature:: [4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-fluorophenyl]acetic acid; With triethylamine; methyl chloroformate; In tetrahydrofuran; at -10 ℃; for 0.5h;

With hydrazine hydrate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 91361-59-0
methyl 2-(2-fluoro-4-hydroxyphenyl)acetate

: 1437779-19-5
2-[4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-fluorophenyl]-acetohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: di-tert-butyl-diazodicarboxylate / dichloromethane / 3 h / 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

2.2: pH 4

3.1: triethylamine; methyl chloroformate / tetrahydrofuran / 0.5 h / -10 °C

3.2: 20 °C

With di-tert-butyl-diazodicarboxylate; water; triethylamine; methyl chloroformate; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;