Benzoic acid (S)-4-(1-azido-1-methyl-ethyl)-cyclohex-1-enylmethyl ester

Base Information

• Chemical Name: Benzoic acid (S)-4-(1-azido-1-methyl-ethyl)-cyclohex-1-enylmethyl ester
• CAS No.: 133744-45-3
• Molecular Formula: C₁₇H₂₁N₃O₂
• Molecular Weight: 299.373
• Mol file: 133744-45-3.mol

Synonyms:Benzoic acid (S)-4-(1-azido-1-methyl-ethyl)-cyclohex-1-enylmethyl ester

Chemical Property of Benzoic acid (S)-4-(1-azido-1-methyl-ethyl)-cyclohex-1-enylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid (S)-4-(1-azido-1-methyl-ethyl)-cyclohex-1-enylmethyl ester

There total 4 articles about Benzoic acid (S)-4-(1-azido-1-methyl-ethyl)-cyclohex-1-enylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(S)-8-Hydroxy-p-menth-1-en-7-yl benzoate (133744-44-2) → Benzoic acid (S)-4-(1-azido-1-methyl-ethyl)-cyclohex-1-enylmethyl ester (133744-45-3)

Guidance literature:

With tris-(2-chloro-ethyl)-amine; boron trifluoride diethyl etherate; In benzene; for 3h; Ambient temperature;

DOI:10.1002/hlca.19910740113

Reference yield:

(-)-perillyl alcohol (536-59-4,18457-55-1) → Benzoic acid (S)-4-(1-azido-1-methyl-ethyl)-cyclohex-1-enylmethyl ester (133744-45-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 23.04 g / 4-pyrrolidinopyridine, pyridine / 1.) 0 deg C, 2 h, 2.) r.t., 14 h

2: 1.) Hg(OAc)2, 2.) NaBH₄, 2.5 N aq. NaOH / 1.) THF, H₂O, r.t., 5 h, 2.) 0 deg C, 30 min

3: 72 percent / HN₃, BF₃*OEt₂ / benzene / 3 h / Ambient temperature

With pyridine; sodium hydroxide; sodium tetrahydroborate; tris-(2-chloro-ethyl)-amine; boron trifluoride diethyl etherate; mercury(II) diacetate; 4-pyrrolidin-1-ylpyridine; In benzene;

DOI:10.1002/hlca.19910740113

Reference yield:

(S)-p-Mentha-1,8-dien-7-yl benzoate (133744-43-1) → Benzoic acid (S)-4-(1-azido-1-methyl-ethyl)-cyclohex-1-enylmethyl ester (133744-45-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Hg(OAc)2, 2.) NaBH₄, 2.5 N aq. NaOH / 1.) THF, H₂O, r.t., 5 h, 2.) 0 deg C, 30 min

2: 72 percent / HN₃, BF₃*OEt₂ / benzene / 3 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; tris-(2-chloro-ethyl)-amine; boron trifluoride diethyl etherate; mercury(II) diacetate; In benzene;

DOI:10.1002/hlca.19910740113

upstream raw materials:

(S)-8-Hydroxy-p-menth-1-en-7-yl benzoate

(-)-perillyl alcohol

(S)-p-Mentha-1,8-dien-7-yl benzoate

benzoyl chloride

Downstream raw materials:

(S)-8-Amino-p-menth-1-en-7-yl benzoate

(R)-8-Amino-p-menth-1-en-7-ol

(S)-8-Amino-p-menth-1-en-7-ol

(S)-7-(Phenylthio)-p-menth-1-en-8-amine