6,8-bis(4-fluorophenyl)-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Base Information

Chemical Name:6,8-bis(4-fluorophenyl)-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one
CAS No.:1641550-54-0
Molecular Formula:C₂₇H₂₀F₂N₂O₂
Molecular Weight:442.465
Hs Code.:

Synonyms:6,8-bis(4-fluorophenyl)-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6,8-bis(4-fluorophenyl)-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property:

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Technology Process of 6,8-bis(4-fluorophenyl)-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

There total 3 articles about 6,8-bis(4-fluorophenyl)-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1641550-46-0
6,8-dibromo-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

: 1765-93-1
4-fluoroboronic acid

: 1641550-54-0
6,8-bis(4-fluorophenyl)-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; XPhos; In water; N,N-dimethyl-formamide; at 120 ℃; Inert atmosphere;
DOI:10.4314/bcse.v28i1.10

Reference yield:

: 28144-70-9,88-68-6
anthranilic acid amide

: 1641550-54-0
6,8-bis(4-fluorophenyl)-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / chloroform; tetrachloromethane / 3 h / 20 °C

2: boric acid / 0.08 h / 120 °C

3: potassium carbonate; XPhos; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 120 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; boric acid; potassium carbonate; XPhos; In tetrachloromethane; chloroform; water; N,N-dimethyl-formamide; 3: |Suzuki-Miyaura Coupling;
DOI:10.4314/bcse.v28i1.10

Reference yield:

: 16524-04-2
2‐amino‐3,5‐dibromobenzamide

: 1641550-54-0
6,8-bis(4-fluorophenyl)-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: boric acid / 0.08 h / 120 °C

2: potassium carbonate; XPhos; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 120 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; boric acid; potassium carbonate; XPhos; In water; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;
DOI:10.4314/bcse.v28i1.10