5-benzyloxy-2-(6,7-dimethoxy-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)-4-methoxybenzaldehyde

Base Information

Chemical Name:5-benzyloxy-2-(6,7-dimethoxy-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)-4-methoxybenzaldehyde
CAS No.:898808-94-1
Molecular Formula:C₂₇H₂₅NO₆
Molecular Weight:459.499
Hs Code.:

Synonyms:5-benzyloxy-2-(6,7-dimethoxy-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)-4-methoxybenzaldehyde

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Chemical Property of 5-benzyloxy-2-(6,7-dimethoxy-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)-4-methoxybenzaldehyde

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Technology Process of 5-benzyloxy-2-(6,7-dimethoxy-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)-4-methoxybenzaldehyde

There total 8 articles about 5-benzyloxy-2-(6,7-dimethoxy-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)-4-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 898808-92-9
3-(4-benzyloxy-2-hydroxymethyl-5-methoxy-phenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-1-one

: 898808-94-1
5-benzyloxy-2-(6,7-dimethoxy-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)-4-methoxybenzaldehyde

Guidance literature:: With dipyridinium dichromate; In dichloromethane; for 2h;
DOI:10.1248/cpb.54.476

Reference yield:

: 898808-83-8
4-benzyloxy-2-formyl-5-methoxybenzonitrile

: 898808-94-1
5-benzyloxy-2-(6,7-dimethoxy-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)-4-methoxybenzaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: 88 percent / NaBH₄; acetic acid / 2 h / 20 °C

2.1: 93 percent / diisopropylethylamine / CH₂Cl₂ / 0 °C

3.1: 30 percent / n-BuLi / tetrahydrofuran / 4 h / -70 °C

4.1: NaH / tetrahydrofuran / 1 h / 0 °C

4.2: 70 percent / tetrahydrofuran / 0 - 60 °C

5.1: 65 percent / aq. HCl / tetrahydrofuran / 3 h / Heating

6.1: 86 percent / PDC / CH₂Cl₂ / 2 h

With hydrogenchloride; sodium tetrahydroborate; dipyridinium dichromate; n-butyllithium; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.54.476

Reference yield:

: 898808-84-9
4-benzyloxy-2-hydroxymethyl-5-methoxybenzonitrile

: 898808-94-1
5-benzyloxy-2-(6,7-dimethoxy-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)-4-methoxybenzaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: 93 percent / diisopropylethylamine / CH₂Cl₂ / 0 °C

2.1: 30 percent / n-BuLi / tetrahydrofuran / 4 h / -70 °C

3.1: NaH / tetrahydrofuran / 1 h / 0 °C

3.2: 70 percent / tetrahydrofuran / 0 - 60 °C

4.1: 65 percent / aq. HCl / tetrahydrofuran / 3 h / Heating

5.1: 86 percent / PDC / CH₂Cl₂ / 2 h

With hydrogenchloride; dipyridinium dichromate; n-butyllithium; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.54.476