(2R,3R,4R,5S)-methyl 3,4-bis(phenylsulfonyl)-5-(pyridin-3-yl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:(2R,3R,4R,5S)-methyl 3,4-bis(phenylsulfonyl)-5-(pyridin-3-yl)pyrrolidine-2-carboxylate
CAS No.:1231660-81-3
Molecular Formula:C₂₃H₂₂N₂O₆S₂
Molecular Weight:486.569
Hs Code.:

Synonyms:(2R,3R,4R,5S)-methyl 3,4-bis(phenylsulfonyl)-5-(pyridin-3-yl)pyrrolidine-2-carboxylate

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Chemical Property of (2R,3R,4R,5S)-methyl 3,4-bis(phenylsulfonyl)-5-(pyridin-3-yl)pyrrolidine-2-carboxylate

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Technology Process of (2R,3R,4R,5S)-methyl 3,4-bis(phenylsulfonyl)-5-(pyridin-3-yl)pyrrolidine-2-carboxylate

There total 4 articles about (2R,3R,4R,5S)-methyl 3,4-bis(phenylsulfonyl)-5-(pyridin-3-yl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 500-22-1
3-pyridinecarboxaldehyde

: 963-16-6
(E)-1,2-bis(phenylsulfonyl)ethylene

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 1231660-81-3
(2R,3R,4R,5S)-methyl 3,4-bis(phenylsulfonyl)-5-(pyridin-3-yl)pyrrolidine-2-carboxylate

Guidance literature:: With silver hexafluoroantimonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); triethylamine; In toluene; at 20 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Darkness;
DOI:10.1055/s-0029-1219534

Reference yield: 83.0%

: 35387-59-8
1,2-Bis(phenylsulfonyl)ethylene

: 479499-38-2
glycine methyl ester (3-pyridinaldehyde)imine

: 1231660-81-3
(2R,3R,4R,5S)-methyl 3,4-bis(phenylsulfonyl)-5-(pyridin-3-yl)pyrrolidine-2-carboxylate

Guidance literature:: With silver hexafluoroantimonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); triethylamine; In toluene; at 25 ℃; for 48h; Solvent; enantioselective reaction; Darkness;
DOI:10.1016/j.tetasy.2012.10.015

Reference yield: 83.0%

: 479499-38-2
glycine methyl ester (3-pyridinaldehyde)imine

: 963-16-6
(E)-1,2-bis(phenylsulfonyl)ethylene

: 1231660-81-3
(2R,3R,4R,5S)-methyl 3,4-bis(phenylsulfonyl)-5-(pyridin-3-yl)pyrrolidine-2-carboxylate

Guidance literature:: With silver hexafluoroantimonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); triethylamine; In toluene; at 20 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Darkness;
DOI:10.1055/s-0029-1219534