tert-butyl (R)-2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (R)-2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate
CAS No.:1422953-47-6
Molecular Formula:C₁₉H₂₇NO₅
Molecular Weight:349.427
Hs Code.:

Synonyms:tert-butyl (R)-2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (R)-2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (R)-2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

There total 2 articles about tert-butyl (R)-2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 916263-26-8
tert-butyl (2R)-2-(2-oxoethyl)pyrrolidine-1-carboxylate

: 2859-78-1
4-Bromoveratrole

: 1422953-47-6
tert-butyl (R)-2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

Guidance literature:: 4-Bromoveratrole; With zinc; In tetrahydrofuran; for 2h; Reflux;

tert-butyl (2R)-2-(2-oxoethyl)pyrrolidine-1-carboxylate; With pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; at 20 ℃; for 3h; Molecular sieve;

Reference yield:

: C₁₉H₂₇NO₅

: 1422953-47-6
tert-butyl (R)-2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

: 138596-88-0
(S)-tert-butyl 2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

Guidance literature:: With (S)-3,3'-bis(triphenylsilyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; In toluene; at -20 ℃; for 18h; Reagent/catalyst; Solvent; Temperature; Time; Overall yield = 93 %; enantioselective reaction;
DOI:10.1039/c2ra22374k

Reference yield: 84.0%

: 104-03-0
4-nitrobenzeneacetic acid

: 1422953-47-6
tert-butyl (R)-2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

: (R)-1-(3,4-dimethoxyphenyl)-2-(1-(2-(4-nitrophenyl)acetyl)pyrrolidin-2-yl)ethan-1-one

Guidance literature:: tert-butyl (R)-2-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

4-nitrobenzeneacetic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 15h;