3-(3,5-bis(trifluoroMethyl)phenylaMino)-4-Methoxycyclobut-3-ene-1,2-dione

Base Information

• Chemical Name: 3-(3,5-bis(trifluoroMethyl)phenylaMino)-4-Methoxycyclobut-3-ene-1,2-dione
• CAS No.: 1223105-85-8
• Molecular Formula: C₁₃H₇F₆NO₃
• Molecular Weight: 339.194
• Mol file: 1223105-85-8.mol

Synonyms:3-(3,5-ditrifluoromethylphenylamino)-4-methoxybutane-3-en-1,2-dione

Chemical Property of 3-(3,5-bis(trifluoroMethyl)phenylaMino)-4-Methoxycyclobut-3-ene-1,2-dione

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-{[3,5-Bis(trifluoromethyl)phenyl]amino}-4-methoxycyclobut-3-ene-1,2-dione >97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3,5-bis(trifluoroMethyl)phenylaMino)-4-Methoxycyclobut-3-ene-1,2-dione

There total 3 articles about 3-(3,5-bis(trifluoroMethyl)phenylaMino)-4-Methoxycyclobut-3-ene-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,4-dimethoxy-3-cyclobutene-1,2-dione (5222-73-1) + 3,5-Bis-(trifluoromethyl)aniline (328-74-5) → 3-(3,5-ditrifluoromethylphenylamino)-4-methoxybutane-3-en-1,2-dione (1223105-85-8)

Guidance literature:

In methanol; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/ol1005104

Reference yield: 67.0%

3,5-ditrifluoromethylisocyanate (16588-74-2) + 3,4-dimethoxy-3-cyclobutene-1,2-dione (5222-73-1) → 3-(3,5-ditrifluoromethylphenylamino)-4-methoxybutane-3-en-1,2-dione (1223105-85-8)

Guidance literature:

With zinc trifluoromethanesulfonate; In methanol; at 20 ℃; for 10h;

DOI:10.1021/acs.orglett.7b02412

Reference yield:

3,4-dimethoxy-3-cyclobutene-1,2-dione + 3,5-Bis-(trifluoromethyl)aniline (328-74-5) → 3-(3,5-ditrifluoromethylphenylamino)-4-methoxybutane-3-en-1,2-dione (1223105-85-8)

Guidance literature:

In methanol; at 25 ℃; for 72h;

DOI:10.1039/c4ra06938b

upstream raw materials:

3,4-dimethoxy-3-cyclobutene-1,2-dione

3,5-Bis-(trifluoromethyl)aniline

3,5-ditrifluoromethylisocyanate

Downstream raw materials:

C₃₂H₂₈F₆N₄O₃

(S)-2-(((2-((3,5-bis(trifluoromethyl)phenyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)methyl)pyrrolidin-1-ium 2,2,2-trifluoroacetate

(S)-3-(3,5-bis(trifluoromethyl)phenylamino)-4-(4-methyl-1-(piperidin-1-yl)pentan-2-ylamino)cyclobut-3-ene-1,2-dione

C₁₈H₁₀F₆N₂O₂