dibutyl (3-(6-fluorobenzo[d]thiazol-2-yl)thioureido)(phenyl)methylphosphonate

Base Information

• Chemical Name: dibutyl (3-(6-fluorobenzo[d]thiazol-2-yl)thioureido)(phenyl)methylphosphonate
• CAS No.: 1352612-49-7
• Molecular Formula: C₂₃H₂₉FN₃O₃PS₂
• Molecular Weight: 509.606
• Mol file: 1352612-49-7.mol

Synonyms:dibutyl (3-(6-fluorobenzo[d]thiazol-2-yl)thioureido)(phenyl)methylphosphonate

Chemical Property of dibutyl (3-(6-fluorobenzo[d]thiazol-2-yl)thioureido)(phenyl)methylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibutyl (3-(6-fluorobenzo[d]thiazol-2-yl)thioureido)(phenyl)methylphosphonate

There total 5 articles about dibutyl (3-(6-fluorobenzo[d]thiazol-2-yl)thioureido)(phenyl)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.9%

2-amino-6-fluoro-1,3-benzothiazole (348-40-3) + O,O'-di-n-butyl isothiocyanato(phenyl)methylphosphonate (1192761-60-6) → dibutyl (3-(6-fluorobenzo[d]thiazol-2-yl)thioureido)(phenyl)methylphosphonate (1352612-49-7)

Guidance literature:

In acetonitrile; at 90 ℃; for 0.5h; Microwave irradiation;

DOI:10.1080/10426507.2011.575422

Reference yield:

C7H8O3S*C15H26NO3P (1038997-74-8) → dibutyl (3-(6-fluorobenzo[d]thiazol-2-yl)thioureido)(phenyl)methylphosphonate (1352612-49-7)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium hydroxide

2: bis(trichloromethyl) carbonate; triethylamine / diethyl ether

3: acetonitrile / 0.5 h / 90 °C / Microwave irradiation

With ammonium hydroxide; bis(trichloromethyl) carbonate; triethylamine; In diethyl ether; acetonitrile;

DOI:10.1080/10426507.2011.575422

Reference yield:

C22H30NO3P → dibutyl (3-(6-fluorobenzo[d]thiazol-2-yl)thioureido)(phenyl)methylphosphonate (1352612-49-7)

Guidance literature:

Multi-step reaction with 4 steps

1: water

2: ammonium hydroxide

3: bis(trichloromethyl) carbonate; triethylamine / diethyl ether

4: acetonitrile / 0.5 h / 90 °C / Microwave irradiation

With ammonium hydroxide; bis(trichloromethyl) carbonate; triethylamine; In diethyl ether; water; acetonitrile;

DOI:10.1080/10426507.2011.575422

upstream raw materials:

2-amino-6-fluoro-1,3-benzothiazole

O,O'-di-n-butyl isothiocyanato(phenyl)methylphosphonate

C₇H₈O₃S*C₁₅H₂₆NO₃P

benzaldehyde