N-[(1R,4S,5S,7R)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]non-7-yl]-3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propionamide

Base Information

Chemical Name:N-[(1R,4S,5S,7R)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]non-7-yl]-3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propionamide
CAS No.:881686-31-3
Molecular Formula:C₄₀H₅₃N₃O₃
Molecular Weight:623.879
Hs Code.:

N-[(1R,4S,5S,7R)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]non-7-yl]-3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propionamide

Synonyms:N-[(1R,4S,5S,7R)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]non-7-yl]-3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propionamide

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Chemical Property of N-[(1R,4S,5S,7R)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]non-7-yl]-3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propionamide

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Technology Process of N-[(1R,4S,5S,7R)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]non-7-yl]-3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propionamide

There total 8 articles about N-[(1R,4S,5S,7R)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]non-7-yl]-3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 881733-72-8
3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propionoic acid

: 444904-17-0
(-)-(1R,4S,5S,7R)-5-[3-(1-methylethoxy)phenyl]-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-amine

: 881686-31-3
N-[(1R,4S,5S,7R)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]non-7-yl]-3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propionamide

Guidance literature:: 3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propionoic acid; (-)-(1R,4S,5S,7R)-5-[3-(1-methylethoxy)phenyl]-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-amine; With triethylamine; In dichloromethane; for 0.333333h;

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; for 4h;
DOI:10.1021/jm058264p

Reference yield:

: 881685-99-0
(1R,4S,5S,7R)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]nonan-7-amine

: 881686-31-3
N-[(1R,4S,5S,7R)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]non-7-yl]-3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 62 percent / toluene / Heating

2.1: 1-chloroethyl chloroformate / CH₂Cl₂ / 3.5 h / Heating

2.2: methanol / Heating

3.1: 84 percent / sodium triacetoxyborohydride / CH₂Cl₂ / 20 °C

4.1: 97 percent / hydrazine / ethanol / Heating

5.1: triethylamine / CH₂Cl₂ / 0.33 h

5.2: 71 percent / 1-ethyl-3-(dimethylaminopropyl)carbodiimide; HOBt / CH₂Cl₂ / 4 h

With carbonochloridic acid 1-chloro-ethyl ester; sodium tris(acetoxy)borohydride; triethylamine; hydrazine; In ethanol; dichloromethane; toluene;
DOI:10.1021/jm058264p

Reference yield:

: 881685-98-9
(1R,4S,5R)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]nonan-7-one oxime

: 881686-31-3
N-[(1R,4S,5S,7R)-5-(3-isopropoxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]non-7-yl]-3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propionamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / Na; isopropanol / toluene / Heating

2.1: 62 percent / toluene / Heating

3.1: 1-chloroethyl chloroformate / CH₂Cl₂ / 3.5 h / Heating

3.2: methanol / Heating

4.1: 84 percent / sodium triacetoxyborohydride / CH₂Cl₂ / 20 °C

5.1: 97 percent / hydrazine / ethanol / Heating

6.1: triethylamine / CH₂Cl₂ / 0.33 h

6.2: 71 percent / 1-ethyl-3-(dimethylaminopropyl)carbodiimide; HOBt / CH₂Cl₂ / 4 h

With carbonochloridic acid 1-chloro-ethyl ester; sodium; sodium tris(acetoxy)borohydride; triethylamine; isopropyl alcohol; hydrazine; In ethanol; dichloromethane; toluene;
DOI:10.1021/jm058264p