terf-butyl benzyl((triisopropylsilyl)ethynyl)carbamate

Base Information

• Chemical Name: terf-butyl benzyl((triisopropylsilyl)ethynyl)carbamate
• CAS No.: 1085526-69-7
• Molecular Formula: C₂₃H₃₇NO₂Si
• Molecular Weight: 387.638
• Mol file: 1085526-69-7.mol

Synonyms:terf-butyl benzyl((triisopropylsilyl)ethynyl)carbamate

Chemical Property of terf-butyl benzyl((triisopropylsilyl)ethynyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of terf-butyl benzyl((triisopropylsilyl)ethynyl)carbamate

There total 4 articles about terf-butyl benzyl((triisopropylsilyl)ethynyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-tert-butoxycarbonylbenzylamine (42116-44-9) + 1-bromo-2-(triisopropylsilyl)acetylene (111409-79-1) → terf-butyl benzyl((triisopropylsilyl)ethynyl)carbamate (1085526-69-7)

Guidance literature:

With potassium phosphate; 1,10-Phenanthroline; copper(II) sulfate; In toluene; at 80 ℃; for 67h; Inert atmosphere;

DOI:10.1021/jo801935b

Reference yield:

tris-iso-propylsilyl acetylene (89343-06-6) → terf-butyl benzyl((triisopropylsilyl)ethynyl)carbamate (1085526-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate / acetone / 2 h / 20 °C

2: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 48 h / 85 °C / Inert atmosphere

With N-Bromosuccinimide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; silver nitrate; In acetone; toluene;

DOI:10.1039/c6cc00370b

Reference yield:

benzylamine (100-46-9) → terf-butyl benzyl((triisopropylsilyl)ethynyl)carbamate (1085526-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline; potassium phosphate / toluene / 24 h / 85 °C / Inert atmosphere

With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; triethylamine; In dichloromethane; toluene;

DOI:10.1002/adsc.201200903

upstream raw materials:

N-tert-butoxycarbonylbenzylamine

1-bromo-2-(triisopropylsilyl)acetylene

benzylamine

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl benzyl(ethynyl)carbamate