ethyl <(1R,2S)-6-amino-4-<<2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl>amino>-5-nitropyridin-2-yl>carbamate

Base Information

• Chemical Name: ethyl <(1R,2S)-6-amino-4-<<2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl>amino>-5-nitropyridin-2-yl>carbamate
• CAS No.: 139068-49-8
• Molecular Formula: C₁₇H₂₁N₅O₆
• Molecular Weight: 391.384

Synonyms:ethyl <(1R,2S)-6-amino-4-<<2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl>amino>-5-nitropyridin-2-yl>carbamate

Chemical Property of ethyl <(1R,2S)-6-amino-4-<<2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl>amino>-5-nitropyridin-2-yl>carbamate

Chemical Property:

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Technology Process of ethyl <(1R,2S)-6-amino-4-<<2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl>amino>-5-nitropyridin-2-yl>carbamate

There total 2 articles about ethyl <(1R,2S)-6-amino-4-<<2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl>amino>-5-nitropyridin-2-yl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate (6506-86-1) + (2R,3R)-2,3-Dihydroxy-succinic acid; compound with 4-((1S,2R)-2-amino-1-hydroxy-propyl)-phenol (1700-73-8,1700-74-9) → ethyl <(1R,2S)-6-amino-4-<<2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl>amino>-5-nitropyridin-2-yl>carbamate (139068-49-8)

Guidance literature:

With triethylamine; In ethanol; for 21h; Heating;

DOI:10.1021/jm00084a003

Reference yield:

ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate (6506-86-1) + (2S,3S)-2,3-Dihydroxy-succinic acid; compound with 4-((1R,2S)-2-amino-1-hydroxy-propyl)-phenol (139016-56-1) → ethyl <(1S,2R)-6-amino-4-<<2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl>amino>-5-nitropyridin-2-yl>carbamate (139068-50-1) + ethyl <(1R,2S)-6-amino-4-<<2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl>amino>-5-nitropyridin-2-yl>carbamate (139068-49-8)

Guidance literature:

With triethylamine; In ethanol; for 21h; Title compound not separated from byproducts; Heating;

DOI:10.1021/jm00084a003

Reference yield: 95.0%

ethyl <(1R,2S)-6-amino-4-<<2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl>amino>-5-nitropyridin-2-yl>carbamate (139068-49-8) → ethyl <(1S,2R)-5,6-diamino-4-<<2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl>amino>pyridin-2-yl>carbamate (143858-92-8)

Guidance literature:

With hydrogen; nickel; In ethanol; for 6h; Ambient temperature;

DOI:10.1021/jm00098a014

upstream raw materials:

ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate

(2S,3S)-2,3-Dihydroxy-succinic acid; compound with 4-((1R,2S)-2-amino-1-hydroxy-propyl)-phenol

(2R,3R)-2,3-Dihydroxy-succinic acid; compound with 4-((1S,2R)-2-amino-1-hydroxy-propyl)-phenol

Downstream raw materials:

ethyl <(R)-6-amino-4-<<2-(4-hydroxyphenyl)-1-methyl-2-oxoethyl>amino>-5-nitropyridine-2-yl>carbamate

ethyl <(1S,2R)-5,6-diamino-4-<<2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl>amino>pyridin-2-yl>carbamate

ethyl <(R)-5-amino-1,2-dihydro-3-(4-hydroxyphenyl)-2-methylpyrido<3,4-b>pyrazin-7-yl>carbamate

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