3-(12-tert-butoxycarbonylamino-dodecyloxy)-5-[2-(4-nitro-phenylamino)-ethoxy]-benzoic acid methyl ester

Base Information

Chemical Name:3-(12-tert-butoxycarbonylamino-dodecyloxy)-5-[2-(4-nitro-phenylamino)-ethoxy]-benzoic acid methyl ester
CAS No.:849100-78-3
Molecular Formula:C₃₃H₄₉N₃O₈
Molecular Weight:615.767
Hs Code.:

3-(12-<i>tert</i>-butoxycarbonylamino-dodecyloxy)-5-[2-(4-nitro-phenylamino)-ethoxy]-benzoic acid methyl ester

Synonyms:3-(12-tert-butoxycarbonylamino-dodecyloxy)-5-[2-(4-nitro-phenylamino)-ethoxy]-benzoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(12-tert-butoxycarbonylamino-dodecyloxy)-5-[2-(4-nitro-phenylamino)-ethoxy]-benzoic acid methyl ester

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Technology Process of 3-(12-tert-butoxycarbonylamino-dodecyloxy)-5-[2-(4-nitro-phenylamino)-ethoxy]-benzoic acid methyl ester

There total 5 articles about 3-(12-tert-butoxycarbonylamino-dodecyloxy)-5-[2-(4-nitro-phenylamino)-ethoxy]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 3-(2-amino-ethoxy)-5-(12-tert-butoxycarbonylamino-dodecyloxy)-benzoic acid methyl ester; hydrochloride

: 849100-78-3
3-(12-tert-butoxycarbonylamino-dodecyloxy)-5-[2-(4-nitro-phenylamino)-ethoxy]-benzoic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 100 ℃;
DOI:10.1002/ejoc.200400609

Reference yield:

: 2150-44-9
1-carbomethoxy-3,5-dihydroxybenzene

: 849100-78-3
3-(12-tert-butoxycarbonylamino-dodecyloxy)-5-[2-(4-nitro-phenylamino)-ethoxy]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 39 percent / potassium carbonate / dimethylformamide / 72 h / 40 °C

2: 88 percent / potassium carbonate / dimethylformamide / 40 °C

3: 97 percent / hydrogen / Pd/C / ethanol; CHCl₃ / 2250.18 Torr

4: 82 percent / diisopropylethyl amine / N,N-dimethyl-acetamide / 100 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; chloroform; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200400609

Reference yield:

: 154371-97-8
12-((tert-butoxycarbonyl)amino)dodecyl methanesulfonate

: 849100-78-3
3-(12-tert-butoxycarbonylamino-dodecyloxy)-5-[2-(4-nitro-phenylamino)-ethoxy]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 39 percent / potassium carbonate / dimethylformamide / 72 h / 40 °C

2: 88 percent / potassium carbonate / dimethylformamide / 40 °C

3: 97 percent / hydrogen / Pd/C / ethanol; CHCl₃ / 2250.18 Torr

4: 82 percent / diisopropylethyl amine / N,N-dimethyl-acetamide / 100 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; chloroform; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200400609