3,4-Didehydro-2-ketoglutaric acid

Base Information

Chemical Name:3,4-Didehydro-2-ketoglutaric acid
CAS No.:6004-32-6
Molecular Formula:C5H4 O5
Molecular Weight:144.084
Hs Code.:2918300090
Nikkaji Number:J761.839E
ChEMBL ID:CHEMBL4847806
Mol file:6004-32-6.mol

Synonyms:2-oxoglutaconic acid;3,4-didehydro-2-ketoglutaric acid;3-ene-2-ketoglutarate

Suppliers and Price of 3,4-Didehydro-2-ketoglutaric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 3,4-Didehydro-2-ketoglutaric acid

Chemical Property:

Vapor Pressure:3.23E-05mmHg at 25°C
Boiling Point:330.5°C at 760 mmHg
Flash Point:167.9°C
PSA：91.67000
Density:1.582
LogP:-0.71910
XLogP3:-0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:144.00587322
Heavy Atom Count:10
Complexity:202

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(=CC(=O)O)C(=O)C(=O)O
Isomeric SMILES:C(=C/C(=O)O)\C(=O)C(=O)O

Technology Process of 3,4-Didehydro-2-ketoglutaric acid

There total 5 articles about 3,4-Didehydro-2-ketoglutaric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 38256-25-6
dimethyl (E)-2-oxoglutaconate

: 6004-32-6
(E)-4-oxopent-2-enedioic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2021.116141

Reference yield:

: dimethyl 2-chloro-4-methylenepentanedioate

: 6004-32-6
(E)-4-oxopent-2-enedioic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrachloromethane; sodium periodate; ruthenium tetroxide / acetonitrile

2: lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

With tetrachloromethane; sodium periodate; ruthenium tetroxide; lithium hydroxide; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.bmc.2021.116141