1-[1-(2,4-Diamino-benzoyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one

Base Information

Chemical Name:1-[1-(2,4-Diamino-benzoyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one
CAS No.:131631-36-2
Molecular Formula:C₂₁H₂₄N₄O₂
Molecular Weight:364.447
Hs Code.:

Synonyms:1-[1-(2,4-Diamino-benzoyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one

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Chemical Property of 1-[1-(2,4-Diamino-benzoyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one

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Technology Process of 1-[1-(2,4-Diamino-benzoyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one

There total 4 articles about 1-[1-(2,4-Diamino-benzoyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 176547-23-2
{3-Benzyloxycarbonylamino-4-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-carbamic acid benzyl ester

: 131631-36-2
1-[1-(2,4-Diamino-benzoyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;
DOI:10.1248/cpb.44.725

Reference yield:

: 90437-31-3
2,4-diamino-benzoic acid ethyl ester

: 131631-36-2
1-[1-(2,4-Diamino-benzoyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / aq. NaHCO₃ / diethyl ether / 5 h / Ambient temperature

2: 54 percent / aq. NaOH / dioxane / Ambient temperature

3: 48 percent / Et₃N, bis(2-oxo-3-oxazolydinyl)phosphinic chloride / CH₂Cl₂ / 1 h / Ambient temperature

4: 17 percent / H₂ / 5percent Pd/C / ethanol / Ambient temperature

With sodium hydroxide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane;
DOI:10.1248/cpb.44.725

Reference yield:

: 176547-19-6
2,4-Bis-benzyloxycarbonylamino-benzoic acid

: 131631-36-2
1-[1-(2,4-Diamino-benzoyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / Et₃N, bis(2-oxo-3-oxazolydinyl)phosphinic chloride / CH₂Cl₂ / 1 h / Ambient temperature

2: 17 percent / H₂ / 5percent Pd/C / ethanol / Ambient temperature

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1248/cpb.44.725