4-{4-[benzyloxycarbonylamino-(hydroxy-phenyl-phosphinoyl)-methyl]-phenylcarbamoyl}-butyric acid

Base Information

Chemical Name:4-{4-[benzyloxycarbonylamino-(hydroxy-phenyl-phosphinoyl)-methyl]-phenylcarbamoyl}-butyric acid
CAS No.:374789-13-6
Molecular Formula:C₂₆H₂₇N₂O₇P
Molecular Weight:510.483
Hs Code.:

Synonyms:4-{4-[benzyloxycarbonylamino-(hydroxy-phenyl-phosphinoyl)-methyl]-phenylcarbamoyl}-butyric acid

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Chemical Property of 4-{4-[benzyloxycarbonylamino-(hydroxy-phenyl-phosphinoyl)-methyl]-phenylcarbamoyl}-butyric acid

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Technology Process of 4-{4-[benzyloxycarbonylamino-(hydroxy-phenyl-phosphinoyl)-methyl]-phenylcarbamoyl}-butyric acid

There total 5 articles about 4-{4-[benzyloxycarbonylamino-(hydroxy-phenyl-phosphinoyl)-methyl]-phenylcarbamoyl}-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 374789-14-7
4-{4-[benzyloxycarbonylamino-(methoxy-phenyl-phosphinoyl)-methyl]-phenylcarbamoyl}-butyric acid

: 374789-13-6
4-{4-[benzyloxycarbonylamino-(hydroxy-phenyl-phosphinoyl)-methyl]-phenylcarbamoyl}-butyric acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 19h;
DOI:10.1002/1521-3765(20010903)7:17<3748::AID-CHEM3748>3.0.CO;2-G

Reference yield:

: 621-84-1
O-benzyl carbamate

: 374789-13-6
4-{4-[benzyloxycarbonylamino-(hydroxy-phenyl-phosphinoyl)-methyl]-phenylcarbamoyl}-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / AcOH / 1 h / Heating

2: 82 percent / N₂H₄*H₂O / 10percent Pd/C / ethanol / 4 h / Heating

3: 12.7 g / pyridine; DMAP / 2 h / Heating

With pyridine; dmap; hydrazine hydrate; acetic acid; 10percent Pd/C; In ethanol;
DOI:10.1002/1521-3765(20010903)7:17<3748::AID-CHEM3748>3.0.CO;2-G

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 374789-13-6
4-{4-[benzyloxycarbonylamino-(hydroxy-phenyl-phosphinoyl)-methyl]-phenylcarbamoyl}-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / AcOH / 1 h / Heating

2: 82 percent / N₂H₄*H₂O / 10percent Pd/C / ethanol / 4 h / Heating

3: 12.7 g / pyridine; DMAP / 2 h / Heating

With pyridine; dmap; hydrazine hydrate; acetic acid; 10percent Pd/C; In ethanol;
DOI:10.1002/1521-3765(20010903)7:17<3748::AID-CHEM3748>3.0.CO;2-G