3-chloro-N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-[1,4]diazepan-1-yl}-pyridin-3-yl)-benzamide

Base Information

Chemical Name:3-chloro-N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-[1,4]diazepan-1-yl}-pyridin-3-yl)-benzamide
CAS No.:1253383-75-3
Molecular Formula:C₂₄H₂₆Cl₂N₆O₂
Molecular Weight:501.415
Hs Code.:

Synonyms:3-chloro-N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-[1,4]diazepan-1-yl}-pyridin-3-yl)-benzamide

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Chemical Property of 3-chloro-N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-[1,4]diazepan-1-yl}-pyridin-3-yl)-benzamide

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Technology Process of 3-chloro-N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-[1,4]diazepan-1-yl}-pyridin-3-yl)-benzamide

There total 3 articles about 3-chloro-N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-[1,4]diazepan-1-yl}-pyridin-3-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1253572-77-8
3-chloro-N-(5-chloro-2-[1,4]diazepan-1-yl-pyridin-3-yl)-benzamide

: 16034-49-4
2-(3,5-dimethyl-1H-pyrazol-1-yl)acetic acid

: 1253383-75-3
3-chloro-N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-[1,4]diazepan-1-yl}-pyridin-3-yl)-benzamide

Guidance literature:: 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetic acid; With pyridine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; for 1h;

3-chloro-N-(5-chloro-2-[1,4]diazepan-1-yl-pyridin-3-yl)-benzamide; In N,N-dimethyl-formamide;

Reference yield:

: 1313190-83-8
C₁₅H₂₁ClN₄O₄

: 1253383-75-3
3-chloro-N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-[1,4]diazepan-1-yl}-pyridin-3-yl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 1 h / 760.05 Torr

2: acetonitrile

3: hydrogenchloride / 1,4-dioxane; acetonitrile / 48 h / 20 °C

4: pyridine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h

With pyridine; hydrogenchloride; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 618-46-2
m-Chlorobenzoyl chloride

: 1253383-75-3
3-chloro-N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-[1,4]diazepan-1-yl}-pyridin-3-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile

2: hydrogenchloride / 1,4-dioxane; acetonitrile / 48 h / 20 °C

3: pyridine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h

With pyridine; hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;