(S)-N-(1-Methyl-2-oxo-4-phenyl-3-butenyl)carbamidsaeure-ethylester

Base Information

• Chemical Name: (S)-N-(1-Methyl-2-oxo-4-phenyl-3-butenyl)carbamidsaeure-ethylester
• CAS No.: 107673-69-8
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.294
• Mol file: 107673-69-8.mol

Synonyms:(S)-N-(1-Methyl-2-oxo-4-phenyl-3-butenyl)carbamidsaeure-ethylester

Chemical Property of (S)-N-(1-Methyl-2-oxo-4-phenyl-3-butenyl)carbamidsaeure-ethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(1-Methyl-2-oxo-4-phenyl-3-butenyl)carbamidsaeure-ethylester

There total 1 articles about (S)-N-(1-Methyl-2-oxo-4-phenyl-3-butenyl)carbamidsaeure-ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

N-ethoxycarbonyl-L-alanine (16639-86-4) + (E)-2-phenylethenyllithium (4843-72-5,6160-69-6,62839-69-4) → (S)-N-(1-Methyl-2-oxo-4-phenyl-3-butenyl)carbamidsaeure-ethylester (107673-69-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; pentane; 1.) -120 deg C / -90 deg C, 15 min, 2.) RT, 1 h;

DOI:10.1002/hlca.19860690420

Reference yield: 92.0%

(S)-N-(1-Methyl-2-oxo-4-phenyl-3-butenyl)carbamidsaeure-ethylester (107673-69-8) → (1S,2RS)-N-(2-Hydroxy-1-Methyl-4-phenyl-3-butenyl)carbamidsaeure-ethylester

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h;

DOI:10.1002/hlca.19860690420

Reference yield:

(S)-N-(1-Methyl-2-oxo-4-phenyl-3-butenyl)carbamidsaeure-ethylester (107673-69-8) → (3R,4S)-4-Amino-1-phenyl-1-penten-3-ol (107673-74-5,96861-89-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / NaBH₄ / methanol / 1 h / 0 °C

2: 1M KOH / methanol / 4 h / Ambient temperature

3: 85 percent / KOH / methanol; H₂O / 18 h / Heating

With potassium hydroxide; sodium tetrahydroborate; In methanol; water;

DOI:10.1002/hlca.19860690420

upstream raw materials:

N-ethoxycarbonyl-L-alanine

(E)-2-phenylethenyllithium

Downstream raw materials:

(3R,4S)-4-Amino-1-phenyl-1-penten-3-ol

(4S,5S)-4-Methyl-5-styryl-2-oxazolidinon

(4S,5R)-4-Methyl-5-styryl-2-oxazolidinon