N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenylcarbamothioyl)cyclopentanecarboxamide

Base Information

Chemical Name:N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenylcarbamothioyl)cyclopentanecarboxamide
CAS No.:1185281-12-2
Molecular Formula:C₂₄H₂₆N₄O₂S
Molecular Weight:434.562
Hs Code.:

Synonyms:N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenylcarbamothioyl)cyclopentanecarboxamide

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Chemical Property of N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenylcarbamothioyl)cyclopentanecarboxamide

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Technology Process of N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenylcarbamothioyl)cyclopentanecarboxamide

There total 15 articles about N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenylcarbamothioyl)cyclopentanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4524-93-0
Cyclopentanecarboxylic acid chloride

: 1021535-31-8
3-(5-amino-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one

: ammonium thiocyanate

: 1185281-12-2
N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenylcarbamothioyl)cyclopentanecarboxamide

Guidance literature:: Cyclopentanecarboxylic acid chloride; ammonium thiocyanate; In acetone; at 40 ℃; for 3h;

3-(5-amino-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one; In acetone; at 20 ℃; for 0.5h;

Reference yield:

: 409082-11-7
2-(2-methyl-5-nitrophenyl)acetonitrile

: 1185281-12-2
N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenylcarbamothioyl)cyclopentanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; potassium hydroxide / methanol / 14 h / Reflux

2.1: hydrogenchloride / 1,4-dioxane / 14 h / Reflux

2.2: pH > 12

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation

6.1: acetone / 3 h / 40 °C

6.2: 0.5 h / 20 °C

With hydrogenchloride; water; hydrogen; potassium carbonate; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; triphenylphosphine; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1185281-12-2
N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenylcarbamothioyl)cyclopentanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation

3.1: acetone / 3 h / 40 °C

3.2: 0.5 h / 20 °C

With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In 1,4-dioxane; N,N-dimethyl-formamide; acetone; toluene;