(S)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (1R,2R)-1-[((S)-1-benzyloxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butyl ester

Base Information

Chemical Name:(S)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (1R,2R)-1-[((S)-1-benzyloxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butyl ester
CAS No.:182205-72-7
Molecular Formula:C₂₅H₄₀N₂O₆
Molecular Weight:464.602
Hs Code.:

Synonyms:(S)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (1R,2R)-1-[((S)-1-benzyloxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butyl ester

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Chemical Property of (S)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (1R,2R)-1-[((S)-1-benzyloxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butyl ester

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Technology Process of (S)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (1R,2R)-1-[((S)-1-benzyloxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butyl ester

There total 11 articles about (S)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (1R,2R)-1-[((S)-1-benzyloxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,3R)-2-[2-(tert-Butoxycarbonyl-methyl-amino)-3-hydroxy-3-methyl-butyryloxy]-3-methyl-pentanoic acid benzyl ester

: 182205-72-7
(S)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (1R,2R)-1-[((S)-1-benzyloxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C

2: N-methylmorpholine (NMM), bis(2-oxo-3-oxazolidinyl)phosphinic chloride (Bop-Cl)

3: 50percent TFA / CH₂Cl₂

With 4-methyl-morpholine; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/0040-4039(96)01199-9

Reference yield:

: 182205-76-1
(2R,3R)-2-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butyryloxy]-3-methyl-pentanoic acid benzyl ester

: 182205-72-7
(S)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (1R,2R)-1-[((S)-1-benzyloxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / Ag₂O / dimethylformamide / 18 h / Ambient temperature

2: H₂ / Pd/C

3: N-methylmorpholine (NMM), bis(2-oxo-3-oxazolidinyl)phosphinic chloride (Bop-Cl)

4: 50percent TFA / CH₂Cl₂

With 4-methyl-morpholine; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; trifluoroacetic acid; silver(l) oxide; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)01199-9

Reference yield:

: 182205-77-2
(2R,3R)-2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butyryloxy]-3-methyl-pentanoic acid benzyl ester

: 182205-72-7
(S)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (1R,2R)-1-[((S)-1-benzyloxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C

2: N-methylmorpholine (NMM), bis(2-oxo-3-oxazolidinyl)phosphinic chloride (Bop-Cl)

3: 50percent TFA / CH₂Cl₂

With 4-methyl-morpholine; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/0040-4039(96)01199-9