(2-Ethyl-8-hydroxy-3-(m-trifluoromethylbenzyl)indolizin-1-yl)glyoxylamide

Base Information

Chemical Name:(2-Ethyl-8-hydroxy-3-(m-trifluoromethylbenzyl)indolizin-1-yl)glyoxylamide
CAS No.:177558-96-2
Molecular Formula:C₂₀H₁₇F₃N₂O₃
Molecular Weight:390.362
Hs Code.:

Synonyms:(2-Ethyl-8-hydroxy-3-(m-trifluoromethylbenzyl)indolizin-1-yl)glyoxylamide

Suppliers and Price of (2-Ethyl-8-hydroxy-3-(m-trifluoromethylbenzyl)indolizin-1-yl)glyoxylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2-Ethyl-8-hydroxy-3-(m-trifluoromethylbenzyl)indolizin-1-yl)glyoxylamide

Chemical Property:

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Technology Process of (2-Ethyl-8-hydroxy-3-(m-trifluoromethylbenzyl)indolizin-1-yl)glyoxylamide

There total 11 articles about (2-Ethyl-8-hydroxy-3-(m-trifluoromethylbenzyl)indolizin-1-yl)glyoxylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 177557-01-6
2-[8-Benzyloxy-2-ethyl-3-(3-trifluoromethyl-benzyl)-indolizin-1-yl]-2-oxo-acetamide

: 177558-96-2
(2-Ethyl-8-hydroxy-3-(m-trifluoromethylbenzyl)indolizin-1-yl)glyoxylamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm960395q

Reference yield: 96.0%

: 177558-96-2
(2-Ethyl-8-hydroxy-3-(m-trifluoromethylbenzyl)indolizin-1-yl)glyoxylamide

Guidance literature:

Reference yield:

: 2584-12-5
ethyl 3-hydroxy-2-pyridineacetate

: 177558-96-2
(2-Ethyl-8-hydroxy-3-(m-trifluoromethylbenzyl)indolizin-1-yl)glyoxylamide

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) 60percent NaH / 1.) DMF, 0 deg C, 50 min, 2.) DMF, overnight

2: 92 percent / NaHCO₃ / butan-2-one / 24 h / Heating

3: 82 percent / Et₃N / 90 °C

4: 50percent KOH / dimethylsulfoxide / 140 °C

5: toluene / 1 h / Heating

6: NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

7: tetrahydrofuran / 0 °C

8: aq. NH₄OH / tetrahydrofuran / Ambient temperature

9: 96 percent / H₂ / 10percent Pd/C / ethyl acetate

With potassium hydroxide; ammonium hydroxide; sodium tetrahydroborate; aluminium trichloride; hydrogen; sodium hydride; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; toluene; butanone;
DOI:10.1021/jm960395q