2,2-dimethyl-propionic acid [3-(acetyl-benzyloxy-amino)-1-benzyl-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester

Base Information

Chemical Name:2,2-dimethyl-propionic acid [3-(acetyl-benzyloxy-amino)-1-benzyl-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester
CAS No.:925977-98-6
Molecular Formula:C₃₁H₄₄NO₉P
Molecular Weight:605.665
Hs Code.:

Synonyms:2,2-dimethyl-propionic acid [3-(acetyl-benzyloxy-amino)-1-benzyl-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester

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Chemical Property of 2,2-dimethyl-propionic acid [3-(acetyl-benzyloxy-amino)-1-benzyl-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester

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Technology Process of 2,2-dimethyl-propionic acid [3-(acetyl-benzyloxy-amino)-1-benzyl-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester

There total 3 articles about 2,2-dimethyl-propionic acid [3-(acetyl-benzyloxy-amino)-1-benzyl-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [3-(acetyl-benzyloxy-amino)-1-benzyl-propyl]-phosphonic acid

: 18997-19-8
Chloromethyl pivalate

: 925977-98-6
2,2-dimethyl-propionic acid [3-(acetyl-benzyloxy-amino)-1-benzyl-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 5h;
DOI:10.1016/j.ejmech.2006.06.015

Reference yield:

: 143152-30-1
(1-benzyl-3-oxo-propyl)-phosphonic acid diethyl ester

: 925977-98-6
2,2-dimethyl-propionic acid [3-(acetyl-benzyloxy-amino)-1-benzyl-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 1 h

2.1: NaBH₃CN; HCl / methanol / 2 h / 20 °C

3.1: 92 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

4.1: trimethylsilyl bromide / CH₂Cl₂ / 0 - 20 °C

4.2: H₂O / tetrahydrofuran / 0.08 h

5.1: Et₃N / dimethylformamide / 5 h / 70 °C

With hydrogenchloride; trimethylsilyl bromide; sodium cyanoborohydride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2006.06.015

Reference yield:

: 925977-74-8
[3-benzyloxyamino-1-benzyl-propyl]-phosphonic acid diethyl ester

: 925977-98-6
2,2-dimethyl-propionic acid [3-(acetyl-benzyloxy-amino)-1-benzyl-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

2.1: trimethylsilyl bromide / CH₂Cl₂ / 0 - 20 °C

2.2: H₂O / tetrahydrofuran / 0.08 h

3.1: Et₃N / dimethylformamide / 5 h / 70 °C

With trimethylsilyl bromide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2006.06.015