3',5'-O-(tetraisopropyl-disiloxane-1,3-diyl)-2'-O-phenoxythiocarbonyl-uridine

Base Information

• Chemical Name: 3',5'-O-(tetraisopropyl-disiloxane-1,3-diyl)-2'-O-phenoxythiocarbonyl-uridine
• CAS No.: 76700-78-2
• Molecular Formula: C₂₈H₄₂N₂O₈SSi₂
• Molecular Weight: 622.887
• Mol file: 76700-78-2.mol

Synonyms:3',5'-O-(tetraisopropyl-disiloxane-1,3-diyl)-2'-O-phenoxythiocarbonyl-uridine

Chemical Property of 3',5'-O-(tetraisopropyl-disiloxane-1,3-diyl)-2'-O-phenoxythiocarbonyl-uridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3',5'-O-(tetraisopropyl-disiloxane-1,3-diyl)-2'-O-phenoxythiocarbonyl-uridine

There total 5 articles about 3',5'-O-(tetraisopropyl-disiloxane-1,3-diyl)-2'-O-phenoxythiocarbonyl-uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

phenylcarbonochloridothioate (1005-56-7) + 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (69304-38-7) → 3',5'-O-(tetraisopropyl-disiloxane-1,3-diyl)-2'-O-phenoxythiocarbonyl-uridine (76700-78-2)

Guidance literature:

With dmap; In dichloromethane; for 6h; Ambient temperature;

Reference yield:

1,1,3,3-tetraisopropyldisiloxane (18043-71-5) → 3',5'-O-(tetraisopropyl-disiloxane-1,3-diyl)-2'-O-phenoxythiocarbonyl-uridine (76700-78-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / Cl₂ / CCl₄ / 0.5 h

2: pyridine / Ambient temperature

3: 4-N,N-dimethylaminopyridine / acetonitrile / Ambient temperature

With pyridine; dmap; chlorine; In tetrachloromethane; acetonitrile;

DOI:10.1021/ja00350a052

Reference yield:

uridine (58-96-8) → 3',5'-O-(tetraisopropyl-disiloxane-1,3-diyl)-2'-O-phenoxythiocarbonyl-uridine (76700-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / pyridine

2: 74 percent / pyridine / CH₂Cl₂

With pyridine; In dichloromethane;

DOI:10.1081/NCN-200060347

upstream raw materials:

phenylcarbonochloridothioate

3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

uridine

diisopropylsilanol

Downstream raw materials:

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

2'-deoxyuridine