2-(Hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid

Base Information

Chemical Name:2-(Hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid
CAS No.:70209-83-5
Molecular Formula:C₁₁H₁₂O₃
Molecular Weight:192.214
Hs Code.:
DSSTox Substance ID:DTXSID70990444
Nikkaji Number:J3.269.800J

Synonyms:70209-83-5;2-(hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid;TRANS-2-(HYDROXYMETHYL)-1-PHENYLCYCLOPROPANECARBOXYLIC ACID;22613-99-6;Cyclopropanecarboxylic acid, 2-(hydroxymethyl)-1-phenyl-;SCHEMBL6023093;DTXSID70990444;AKOS017532015;EN300-1153809;2-(hydroxymethyl)-1-phenylcyclopropane-1-carboxylicacid

Suppliers and Price of 2-(Hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-(Hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid

Chemical Property:

Vapor Pressure:1.61E-06mmHg at 25°C
Boiling Point:382.1°Cat760mmHg
Flash Point:199.1°C
PSA：57.53000
Density:1.31g/cm³
LogP:1.02120
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:192.078644241
Heavy Atom Count:14
Complexity:233

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(C1(C2=CC=CC=C2)C(=O)O)CO

Technology Process of 2-(Hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid

There total 6 articles about 2-(Hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 67843-74-7,24969-06-0,13403-37-7
(S)-epichlorohydrin

: 140-29-4
phenylacetonitrile

: 22613-99-6,66823-04-9,70209-83-5,96847-50-6,96847-51-7
(1S,2S)-2-(hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid

: 96847-52-8
(1R,2S)-2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane

Guidance literature:: phenylacetonitrile; With sodium amide; In benzene; at 0 - 20 ℃; for 3h; Inert atmosphere;

(S)-epichlorohydrin; In benzene; at 0 - 20 ℃; for 2h; Further stages; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b01584

Reference yield: 5.2%

: 51594-55-9,24969-06-0,13403-37-7
(R)-(-)-epichlorohydrin

: 140-29-4
phenylacetonitrile

: 22613-99-6,66823-04-9,70209-83-5,96847-50-6,96847-51-7
(1S,2S)-2-(hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid

Guidance literature:: (R)-(-)-epichlorohydrin; phenylacetonitrile; With sodium amide; In toluene; at 0 - 5 ℃;

With water; potassium hydroxide; In toluene; Reflux;