C₁₆H₁₉NO₅

Base Information

Chemical Name:C₁₆H₁₉NO₅
CAS No.:1043880-66-5
Molecular Formula:C₁₆H₁₉NO₅
Molecular Weight:305.331
Hs Code.:

C<sub>16</sub>H<sub>19</sub>NO<sub>5</sub>

Synonyms:C₁₆H₁₉NO₅

Suppliers and Price of C₁₆H₁₉NO₅

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Chemical Property of C₁₆H₁₉NO₅

Chemical Property:

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Technology Process of C₁₆H₁₉NO₅

There total 8 articles about C₁₆H₁₉NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1037368-64-1
2-benzyl 3a-tert-butyl (3aS,7aR)-tetrahydropyrano[3,4-c]pyrrole-2,3a(3H,4H)-dicarboxylate

: 1043880-66-5
C₁₆H₁₉NO₅

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 15h;

Reference yield:

: 915302-93-1
2-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-4-carboxylic acid tert-butyl ester

: 1043880-66-5
C₁₆H₁₉NO₅

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.1: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / 18.5 h / 0 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.83 h / -40 - 0 °C / Inert atmosphere

4.1: sodium tetrahydroborate / water; tetrahydrofuran; ethyl acetate / 10 h / 20 °C / Inert atmosphere

5.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / -10 °C / Inert atmosphere

5.2: 10 h / 40 °C / Inert atmosphere

6.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 24 h / 38002.6 Torr

7.1: borane-THF / tetrahydrofuran / 3 h / 40 °C / Inert atmosphere

7.2: 4 h / 80 °C

7.3: 3 h / 35 °C

8.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

With sodium tetrahydroborate; borane-THF; palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.jmedchem.8b00644

Reference yield:

: C₂₀H₂₅NO₅

: 1043880-66-5
C₁₆H₁₉NO₅

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / water; tetrahydrofuran; ethyl acetate / 10 h / 20 °C / Inert atmosphere

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / -10 °C / Inert atmosphere

2.2: 10 h / 40 °C / Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon; magnesium bromide / ethanol; ethyl acetate / 14 h / 20 °C / 22801.5 Torr / Autoclave

4.1: borane-THF / tetrahydrofuran / 3 h / 40 °C / Inert atmosphere

4.2: 4 h / 80 °C

4.3: 3 h / 35 °C

5.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

With sodium tetrahydroborate; borane-THF; palladium 10% on activated carbon; hydrogen; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; magnesium bromide; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/acs.jmedchem.8b00644