[6-(3-benzyloxy-phenoxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester

Base Information

Chemical Name:[6-(3-benzyloxy-phenoxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester
CAS No.:1265356-53-3
Molecular Formula:C₁₆H₁₅BO₆
Molecular Weight:314.102
Hs Code.:

Synonyms:[6-(3-benzyloxy-phenoxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester

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Chemical Property of [6-(3-benzyloxy-phenoxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester

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Technology Process of [6-(3-benzyloxy-phenoxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester

There total 11 articles about [6-(3-benzyloxy-phenoxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1265360-92-6
[6-(3-benzyloxy-phenoxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid

: 1265356-53-3
[6-(3-benzyloxy-phenoxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; for 0.5h; under 2068.65 Torr;

Reference yield:

: 487-69-4
2,4-dihydroxy-6-methylbenzaldehyde

: 1265356-53-3
[6-(3-benzyloxy-phenoxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 18 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C

3.1: methanol / pyridinium p-toluenesulfonate / 12 h / 20 °C

4.1: triethylamine / copper diacetate / dichloromethane; water / 12 h / 20 °C / 4 ? Molecular sieve

5.1: hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux

6.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

7.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1 h / 80 °C / Inert atmosphere

8.1: chloro-trimethyl-silane; zinc / tetrahydrofuran / 37 - 40 °C

8.2: 3 h / -78 - 20 °C

9.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

9.2: pH 2

10.1: hydrogen / palladium 10% on activated carbon / ethanol / 0.5 h / 2068.65 Torr

With hydrogenchloride; methanol; chloro-trimethyl-silane; water; hydrogen; potassium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; copper diacetate; pyridinium p-toluenesulfonate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 219298-65-4
2-hydroxy-6-methyl-4-(tetrahydropyran-2-yloxy)benzaldehyde

: 1265356-53-3
[6-(3-benzyloxy-phenoxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C

2.1: methanol / pyridinium p-toluenesulfonate / 12 h / 20 °C

3.1: triethylamine / copper diacetate / dichloromethane; water / 12 h / 20 °C / 4 ? Molecular sieve

4.1: hydrogenchloride / tetrahydrofuran; water / 2 h / Reflux

5.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

6.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1 h / 80 °C / Inert atmosphere

7.1: chloro-trimethyl-silane; zinc / tetrahydrofuran / 37 - 40 °C

7.2: 3 h / -78 - 20 °C

8.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

8.2: pH 2

9.1: hydrogen / palladium 10% on activated carbon / ethanol / 0.5 h / 2068.65 Torr

With hydrogenchloride; methanol; chloro-trimethyl-silane; water; hydrogen; potassium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; copper diacetate; pyridinium p-toluenesulfonate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;