N-[3-(6-aminopurin-9-yl)propyl]-6-chloro-2-methoxy-acridin-9-amine

Base Information

• Chemical Name: N-[3-(6-aminopurin-9-yl)propyl]-6-chloro-2-methoxy-acridin-9-amine
• CAS No.: 79953-24-5
• Molecular Formula: C₂₂H₂₀ClN₇O
• Molecular Weight: 433.9
• Mol file: 79953-24-5.mol

Synonyms:N-[3-(6-aminopurin-9-yl)propyl]-6-chloro-2-methoxy-acridin-9-amine

Chemical Property of N-[3-(6-aminopurin-9-yl)propyl]-6-chloro-2-methoxy-acridin-9-amine

Chemical Property:

• Vapor Pressure: 1.27E-21mmHg at 25°C
• Boiling Point: 737.6°C at 760 mmHg
• Flash Point: 399.9°C
• PSA: 107.00000
• Density: 1.49g/cm³
• LogP: 4.27720

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[3-(6-aminopurin-9-yl)propyl]-6-chloro-2-methoxy-acridin-9-amine

There total 4 articles about N-[3-(6-aminopurin-9-yl)propyl]-6-chloro-2-methoxy-acridin-9-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

6-chloro-2-methoxy-9-phenoxyacridine (7478-26-4) + 3-(adenine-9-yl)propylamine (21708-31-6) → 6-chloro-2-methoxy-9-<(3-(aden-9-yl)propyl)amino>acridine (79953-24-5)

Guidance literature:

In various solvent(s); at 120 ℃; for 2h;

DOI:10.1021/ja00367a019

Reference yield:

6-chloro-2-methoxy-9-<(3-hydroxypropyl)amino>acridine (79953-26-7) → 6-chloro-2-methoxy-9-<(3-(aden-9-yl)propyl)amino>acridine (79953-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / 47percent hydrobromic acid, sulfuric acid / 4 h / 70 °C

2: sodium hydride / dimethylformamide / 48 h / Ambient temperature

With sulfuric acid; hydrogen bromide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/ja00367a019

Reference yield:

6-chloro-2-methoxy-9-phenoxyacridine (7478-26-4) → 6-chloro-2-methoxy-9-<(3-(aden-9-yl)propyl)amino>acridine (79953-24-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / dimethylsulfoxide / 12 h / 110 °C

2: 30 percent / 47percent hydrobromic acid, sulfuric acid / 4 h / 70 °C

3: sodium hydride / dimethylformamide / 48 h / Ambient temperature

With sulfuric acid; hydrogen bromide; sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/ja00367a019

upstream raw materials:

6-chloro-2-methoxy-9-phenoxyacridine

3-(adenine-9-yl)propylamine

6-chloro-2-methoxy-9-<(3-bromopropyl)amino>acridine

adenine