2S,4S,5S-6-Cyclohexyl-5-(t-butoxycarbonylamino)-2-(2-methylpropyl)gamma-hexanolactone

Base Information

• Chemical Name: 2S,4S,5S-6-Cyclohexyl-5-(t-butoxycarbonylamino)-2-(2-methylpropyl)gamma-hexanolactone
• CAS No.: 112227-11-9
• Molecular Formula: C₂₁H₃₇NO₄
• Molecular Weight: 367.529
• Mol file: 112227-11-9.mol

Synonyms:2S,4S,5S-6-Cyclohexyl-5-(t-butoxycarbonylamino)-2-(2-methylpropyl)gamma-hexanolactone

Chemical Property of 2S,4S,5S-6-Cyclohexyl-5-(t-butoxycarbonylamino)-2-(2-methylpropyl)gamma-hexanolactone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2S,4S,5S-6-Cyclohexyl-5-(t-butoxycarbonylamino)-2-(2-methylpropyl)gamma-hexanolactone

There total 3 articles about 2S,4S,5S-6-Cyclohexyl-5-(t-butoxycarbonylamino)-2-(2-methylpropyl)gamma-hexanolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2S,4S,5S-6-Cyclohexyl-5-(t-butoxycarbonylamino)-2-(2-methyl-2-propenyl)-gamma-hexanolactone (112227-10-8) → 2S,4S,5S-6-Cyclohexyl-5-(t-butoxycarbonylamino)-2-(2-methylpropyl)gamma-hexanolactone (112227-11-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃;

DOI:10.1016/j.bmcl.2004.02.020

Reference yield:

(5S)-5-[(1S)-1-(N-t-butoxycarbonylamino)-2-cyclohexylethyl]dihydrofuran-2(3H)-one (112227-09-5) → 2S,4S,5S-6-Cyclohexyl-5-(t-butoxycarbonylamino)-2-(2-methylpropyl)gamma-hexanolactone (112227-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 percent / LHMDS / 3 h / -45 °C

2: H₂ / Pd/C / ethanol / 20 °C

With hydrogen; lithium hexamethyldisilazane; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.bmcl.2004.02.020

Reference yield:

→ 2S,4S,5S-6-Cyclohexyl-5-(t-butoxycarbonylamino)-2-(2-methylpropyl)gamma-hexanolactone (112227-11-9)

Guidance literature:

upstream raw materials:

2S,4S,5S-6-Cyclohexyl-5-(t-butoxycarbonylamino)-2-(2-methyl-2-propenyl)-gamma-hexanolactone

(5S)-5-[(1S)-1-(N-t-butoxycarbonylamino)-2-cyclohexylethyl]dihydrofuran-2(3H)-one