dimethyl-carbamic acid 9-benzhydryloxy-7-(4-fluoro-benzyl)-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

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Chemical Name:dimethyl-carbamic acid 9-benzhydryloxy-7-(4-fluoro-benzyl)-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester
CAS No.:684285-12-9
Molecular Formula:C₃₄H₂₆FN₃O₅
Molecular Weight:575.596
Hs Code.:

dimethyl-carbamic acid 9-benzhydryloxy-7-(4-fluoro-benzyl)-6,8-dioxo-7,8-dihydro-6<i>H</i>-pyrrolo[3,4-<i>g</i>]quinolin-5-yl ester

Synonyms:dimethyl-carbamic acid 9-benzhydryloxy-7-(4-fluoro-benzyl)-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

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Chemical Property of dimethyl-carbamic acid 9-benzhydryloxy-7-(4-fluoro-benzyl)-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

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Technology Process of dimethyl-carbamic acid 9-benzhydryloxy-7-(4-fluoro-benzyl)-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

There total 3 articles about dimethyl-carbamic acid 9-benzhydryloxy-7-(4-fluoro-benzyl)-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 684284-29-5
7-(4-fluoro-benzyl)-5,9-dihydroxy-pyrrolo[3,4-g]quinoline-6,8-dione

: 684285-12-9
dimethyl-carbamic acid 9-benzhydryloxy-7-(4-fluoro-benzyl)-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / NaOH / dioxane; H₂O / 1 h / 20 °C

2: 80 percent / 1,2-dichloro-ethane / 3 h / 70 °C

3: 100 percent / K₂CO₃; 4-dimethylaminopyridine / tetrahydrofuran; H₂O / 12 h / 20 °C

4: 50 percent / TEA; DMAP / 1,2-dichloro-ethane / 12 h / 20 °C

With dmap; sodium hydroxide; TEA; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2006.05.016

Reference yield:

: 684284-30-8
carbonic acid ethyl ester 7-(4-fluoro-benzyl)-9-hydroxy-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

: 684285-12-9
dimethyl-carbamic acid 9-benzhydryloxy-7-(4-fluoro-benzyl)-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 1,2-dichloro-ethane / 3 h / 70 °C

2: 100 percent / K₂CO₃; 4-dimethylaminopyridine / tetrahydrofuran; H₂O / 12 h / 20 °C

3: 50 percent / TEA; DMAP / 1,2-dichloro-ethane / 12 h / 20 °C

With dmap; TEA; potassium carbonate; In tetrahydrofuran; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2006.05.016

Reference yield:

: 684284-61-5
carbonic acid 9-benzhydryloxy-7-(4-fluoro-benzyl)-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester ethyl ester

: 684285-12-9
dimethyl-carbamic acid 9-benzhydryloxy-7-(4-fluoro-benzyl)-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / K₂CO₃; 4-dimethylaminopyridine / tetrahydrofuran; H₂O / 12 h / 20 °C

2: 50 percent / TEA; DMAP / 1,2-dichloro-ethane / 12 h / 20 °C

With dmap; TEA; potassium carbonate; In tetrahydrofuran; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2006.05.016