(Z)-5-(2,6-dichlorobenzylsulfonyl)-3-({3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-2-one

Base Information

Chemical Name:(Z)-5-(2,6-dichlorobenzylsulfonyl)-3-({3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-2-one
CAS No.:1235459-49-0
Molecular Formula:C₃₁H₃₃Cl₂N₃O₄S
Molecular Weight:614.593
Hs Code.:

Synonyms:(Z)-5-(2,6-dichlorobenzylsulfonyl)-3-({3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-2-one

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Chemical Property of (Z)-5-(2,6-dichlorobenzylsulfonyl)-3-({3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-2-one

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Technology Process of (Z)-5-(2,6-dichlorobenzylsulfonyl)-3-({3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-2-one

There total 8 articles about (Z)-5-(2,6-dichlorobenzylsulfonyl)-3-({3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 477573-39-0
5-[(2,6-dichlorobenzyl)sulfonyl]-1,3-dihydro-2H-indol-2-one

: 1239441-14-5
3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde

: 1235459-49-0
(Z)-5-(2,6-dichlorobenzylsulfonyl)-3-({3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-2-one

Guidance literature:: With piperidine; In ethanol; for 12h; Reflux;
DOI:10.1039/c4ra08720h

Reference yield:

: N,N-diethyl-3-[4-oxo-1-(phenylsulfonyl)-4,5,6,7-tetrahydro-1Hindol-3-yl]propanamide

: 1235459-49-0
(Z)-5-(2,6-dichlorobenzylsulfonyl)-3-({3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: boron trifluoride diethyl etherate / methanol / 0.75 h / 20 °C

2: sodium hydroxide; methanol / water / 3 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

4: trichlorophosphate

5: mercury dichloride; calcium carbonate; water / acetonitrile

6: piperidine / ethanol / 12 h / Reflux

With piperidine; methanol; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; water; calcium carbonate; mercury dichloride; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; water; acetonitrile;
DOI:10.1039/c4ra08720h

Reference yield:

: N,N-diethyl-3-[1'-(phenylsulfonyl)-1',5',6',7'-tetrahydrospiro[[1,3]dithiolane-2,4'-indole]-3'-yl]propanamide

: 1235459-49-0
(Z)-5-(2,6-dichlorobenzylsulfonyl)-3-({3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; methanol / water / 3 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

3: trichlorophosphate

4: mercury dichloride; calcium carbonate; water / acetonitrile

5: piperidine / ethanol / 12 h / Reflux

With piperidine; methanol; lithium aluminium tetrahydride; water; calcium carbonate; mercury dichloride; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.1039/c4ra08720h