10b-(3,4-dimethoxybenzyl)-8,9-dimethoxy-6,10b-dihydro-5H-thiazolo[2,3-a]isoquinolin-3-one

Base Information

Chemical Name:10b-(3,4-dimethoxybenzyl)-8,9-dimethoxy-6,10b-dihydro-5H-thiazolo[2,3-a]isoquinolin-3-one
CAS No.:269407-38-7
Molecular Formula:C₂₂H₂₅NO₅S
Molecular Weight:415.51
Hs Code.:

Synonyms:10b-(3,4-dimethoxybenzyl)-8,9-dimethoxy-6,10b-dihydro-5H-thiazolo[2,3-a]isoquinolin-3-one

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Chemical Property of 10b-(3,4-dimethoxybenzyl)-8,9-dimethoxy-6,10b-dihydro-5H-thiazolo[2,3-a]isoquinolin-3-one

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Technology Process of 10b-(3,4-dimethoxybenzyl)-8,9-dimethoxy-6,10b-dihydro-5H-thiazolo[2,3-a]isoquinolin-3-one

There total 5 articles about 10b-(3,4-dimethoxybenzyl)-8,9-dimethoxy-6,10b-dihydro-5H-thiazolo[2,3-a]isoquinolin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 2-(3,4-dimethoxybenzylidene)-3-[2-(3,4-dimethoxyphenyl)ethyl]thiazolidin-4-one

: 269407-38-7
10b-(3,4-dimethoxybenzyl)-8,9-dimethoxy-6,10b-dihydro-5H-thiazolo[2,3-a]isoquinolin-3-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1021/jo991742h

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 269407-38-7
10b-(3,4-dimethoxybenzyl)-8,9-dimethoxy-6,10b-dihydro-5H-thiazolo[2,3-a]isoquinolin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride; DMF / benzene / 2 h / 20 °C

2: 8.0 g / CH₂Cl₂ / 2 h / 0 - 20 °C

3: 83 percent / Lawesson's reagent / toluene / 5 h / Heating

4: 84 percent / toluene / 18 h / Heating

5: 93 percent / CF₃COOH / CH₂Cl₂ / 48 h / 20 °C

With Lawessons reagent; oxalyl dichloride; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; toluene; benzene; 1: Substitution / 2: Acylation / 3: Substitution / 4: Acylation / 5: Cyclization;
DOI:10.1021/jo991742h

Reference yield:

: 139-76-4
N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide

: 269407-38-7
10b-(3,4-dimethoxybenzyl)-8,9-dimethoxy-6,10b-dihydro-5H-thiazolo[2,3-a]isoquinolin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Lawesson's reagent / toluene / 5 h / Heating

2: 84 percent / toluene / 18 h / Heating

3: 93 percent / CF₃COOH / CH₂Cl₂ / 48 h / 20 °C

With Lawessons reagent; trifluoroacetic acid; In dichloromethane; toluene; 1: Substitution / 2: Acylation / 3: Cyclization;
DOI:10.1021/jo991742h