(4aR,6S,8aS)-(+)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-1-hydroxymethyl-2,5,5,8a-tetramethylnaphthalene

Base Information

Chemical Name:(4aR,6S,8aS)-(+)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-1-hydroxymethyl-2,5,5,8a-tetramethylnaphthalene
CAS No.:115333-56-7
Molecular Formula:C₂₂H₃₂O₂
Molecular Weight:328.495
Hs Code.:

Synonyms:(4aR,6S,8aS)-(+)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-1-hydroxymethyl-2,5,5,8a-tetramethylnaphthalene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4aR,6S,8aS)-(+)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-1-hydroxymethyl-2,5,5,8a-tetramethylnaphthalene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (4aR,6S,8aS)-(+)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-1-hydroxymethyl-2,5,5,8a-tetramethylnaphthalene

There total 11 articles about (4aR,6S,8aS)-(+)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-1-hydroxymethyl-2,5,5,8a-tetramethylnaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 115333-55-6
Methyl (4aR,6S,8aS)-6-(benzyloxy)-3,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethylnaphthalene-1-carboxylate

: 115333-56-7
(4aR,6S,8aS)-(+)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-1-hydroxymethyl-2,5,5,8a-tetramethylnaphthalene

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.5h;

Reference yield:

: 10247-03-7
methyl (1S,4aR,6S,8aS)-(+)-1,4,4a,5,6,7,8,8a-octahydro-6-hydroxy-2,5,5,8a-tetramethyl-1-naphthalenecarboxylate

: 115333-56-7
(4aR,6S,8aS)-(+)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-1-hydroxymethyl-2,5,5,8a-tetramethylnaphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, rt then 40 deg C 1 h; 2.) DMF, 40 deg C 2 h

2: 59 percent / LAH / diethyl ether / 4 h / Ambient temperature

With lithium aluminium tetrahydride; sodium hydride; In diethyl ether;
DOI:10.1016/S0040-4020(01)81631-8

Reference yield:

: 100-44-7
benzyl chloride

: 115333-56-7
(4aR,6S,8aS)-(+)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-1-hydroxymethyl-2,5,5,8a-tetramethylnaphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, rt then 40 deg C 1 h; 2.) DMF, 40 deg C 2 h

2: 59 percent / LAH / diethyl ether / 4 h / Ambient temperature

With lithium aluminium tetrahydride; sodium hydride; In diethyl ether;
DOI:10.1016/S0040-4020(01)81631-8