2-(1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 1-adamantyl ester

Base Information

• Chemical Name: 2-(1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 1-adamantyl ester
• CAS No.: 1312606-88-4
• Molecular Formula: C₂₉H₃₀ClNO₄
• Molecular Weight: 492.014
• Mol file: 1312606-88-4.mol

Synonyms:2-(1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 1-adamantyl ester

Chemical Property of 2-(1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 1-adamantyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 1-adamantyl ester

There total 2 articles about 2-(1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 1-adamantyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1-adamanthanol (768-95-6) + [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) → 2-(1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 1-adamantyl ester (1312606-88-4)

Guidance literature:

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; for 0.166667h; Inert atmosphere;

1-adamanthanol; In dichloromethane; for 12h; Inert atmosphere;

DOI:10.1016/j.bmc.2011.03.054

Reference yield:

1-adamantyl fluoride (768-92-3) + [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 2-(1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 1-adamantyl ester (1312606-88-4) + 2-fluoro-4,4,5,5-tetramethyl-1,3-dioxa-2-boracyclopentane

Guidance literature:

With 9-bora-bicyclo[3.3.1]nonane; In ethyl acetate; at 20 ℃; for 1h; Overall yield = 92percent;

DOI:10.1021/acscatal.1c00282

upstream raw materials:

1-adamanthanol

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

1-adamantyl fluoride

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane