[2-(4-bromo-6-(2-phenylethynyl)-4'-(trifluoromethyl)biphenyl-3-yl)ethynyl]triisopropylsilane

Base Information

Chemical Name:[2-(4-bromo-6-(2-phenylethynyl)-4'-(trifluoromethyl)biphenyl-3-yl)ethynyl]triisopropylsilane
CAS No.:945891-94-1
Molecular Formula:C₃₂H₃₂BrF₃Si
Molecular Weight:581.591
Hs Code.:

Synonyms:[2-(4-bromo-6-(2-phenylethynyl)-4'-(trifluoromethyl)biphenyl-3-yl)ethynyl]triisopropylsilane

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Chemical Property of [2-(4-bromo-6-(2-phenylethynyl)-4'-(trifluoromethyl)biphenyl-3-yl)ethynyl]triisopropylsilane

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Technology Process of [2-(4-bromo-6-(2-phenylethynyl)-4'-(trifluoromethyl)biphenyl-3-yl)ethynyl]triisopropylsilane

There total 4 articles about [2-(4-bromo-6-(2-phenylethynyl)-4'-(trifluoromethyl)biphenyl-3-yl)ethynyl]triisopropylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 945891-92-9
[2-(4-bromo-6-ethynyl-4'-(trifluoromethyl)biphenyl-3-yl)ethynyl]triisopropylsilane

: 591-50-4
iodobenzene

: 945891-94-1
[2-(4-bromo-6-(2-phenylethynyl)-4'-(trifluoromethyl)biphenyl-3-yl)ethynyl]triisopropylsilane

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1002/ejoc.200700070

Reference yield:

: 945891-89-4
4-bromo-4'-trifluoromethyl-2,5-bis[2-(triisopropylsilyl)ethynyl]biphenyl

: 945891-94-1
[2-(4-bromo-6-(2-phenylethynyl)-4'-(trifluoromethyl)biphenyl-3-yl)ethynyl]triisopropylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: 21 percent / TBAF; acetic acid / tetrahydrofuran / 16 h / 20 °C

2: 86 percent / CuI; diisopropylethylamine / Pd(PPh₃)4 / tetrahydrofuran / 16 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; acetic acid; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2: Sonogashira coupling;
DOI:10.1002/ejoc.200700070

Reference yield:

: 63262-06-6
1,4-dibromo-2,5-diiodobenzene

: 945891-94-1
[2-(4-bromo-6-(2-phenylethynyl)-4'-(trifluoromethyl)biphenyl-3-yl)ethynyl]triisopropylsilane

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / CuI; diisopropylethylamine / Pd(PPh₃)2Cl₂ / tetrahydrofuran / 40 h / 20 °C

2: 46 percent / K₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 14 h / 80 °C

3: 21 percent / TBAF; acetic acid / tetrahydrofuran / 16 h / 20 °C

4: 86 percent / CuI; diisopropylethylamine / Pd(PPh₃)4 / tetrahydrofuran / 16 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1: Sonogashira coupling / 2: Suzuki coupling / 4: Sonogashira coupling;
DOI:10.1002/ejoc.200700070