1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester
• CAS No.: 1026907-72-1
• Molecular Formula: C₃₀H₃₃F₂NO₄
• Molecular Weight: 509.593

Synonyms:1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

Chemical Property of 1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

There total 2 articles about 1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-methanol → 1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester (1026907-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. H₂SO₄ / benzene / 0.33 h / Ambient temperature

2: NaI, K₂CO₃ / dioxane / Heating

With sulfuric acid; potassium carbonate; sodium iodide; In 1,4-dioxane; benzene;

DOI:10.1021/jm00041a012

Reference yield:

C22H19BrF2O2 (1027599-79-6) + Ethyl nipecotate (71962-74-8) → 1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester (1026907-72-1)

Guidance literature:

With potassium carbonate; sodium iodide; In 1,4-dioxane; Heating;

DOI:10.1021/jm00041a012

Reference yield: 61.0%

1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester (1026907-72-1) → 1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid

Guidance literature:

With lithium hydroxide; In ethanol; for 24h; Ambient temperature;

DOI:10.1021/jm00041a012

upstream raw materials:

C₂₂H₁₉BrF₂O₂

Ethyl nipecotate

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