N-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-phenyl-acetamide

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Chemical Name:N-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-phenyl-acetamide
CAS No.:136112-92-0
Molecular Formula:C₃₀H₄₇N₅O₅Si₂
Molecular Weight:613.905
Hs Code.:
Mol file:136112-92-0.mol

<i>N</i>-{9-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1<i>H</i>-purin-2-yl}-2-phenyl-acetamide

Synonyms:N-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-phenyl-acetamide

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Chemical Property of N-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-phenyl-acetamide Edit

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Technology Process of N-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-phenyl-acetamide

There total 2 articles about N-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-phenyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 934500-67-1
2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester

: 136112-92-0
N-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-phenyl-acetamide

Guidance literature:: With diphenyl(methyl)phosphine; 2-hydroxyethanethiol; In 1,4-dioxane; water; at 20 ℃; for 0.166667h;
DOI:10.1016/j.tetlet.2007.01.064

Reference yield:

: 934500-66-0
2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester

: 136112-92-0
N-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-methylpyrrolidine / CH₂Cl₂ / 0.17 h / 0 °C

1.2: 77 percent / DBU / CH₂Cl₂ / 1.5 h / 0 °C

2.1: 100 percent / MePPh₂; 2-mercaptoethanol / dioxane; H₂O / 0.17 h / 20 °C

With 1-Methylpyrrolidine; diphenyl(methyl)phosphine; 2-hydroxyethanethiol; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.tetlet.2007.01.064