(E)-trimethyl(4-(tetrahydro-2H-pyran-2-yloxy)-1-(p-tolyl)but-1-enyl)silane

Base Information

• Chemical Name: (E)-trimethyl(4-(tetrahydro-2H-pyran-2-yloxy)-1-(p-tolyl)but-1-enyl)silane
• CAS No.: 1453869-17-4
• Molecular Formula: C₁₉H₃₀O₂Si
• Molecular Weight: 318.531
• Mol file: 1453869-17-4.mol

Synonyms:(E)-trimethyl(4-(tetrahydro-2H-pyran-2-yloxy)-1-(p-tolyl)but-1-enyl)silane

Chemical Property of (E)-trimethyl(4-(tetrahydro-2H-pyran-2-yloxy)-1-(p-tolyl)but-1-enyl)silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-trimethyl(4-(tetrahydro-2H-pyran-2-yloxy)-1-(p-tolyl)but-1-enyl)silane

There total 2 articles about (E)-trimethyl(4-(tetrahydro-2H-pyran-2-yloxy)-1-(p-tolyl)but-1-enyl)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-tolyl iodide (624-31-7) + (Z)-triethoxy(4-(tetrahydro-2H-pyran-2-yloxy)-1-(trimethylsilyl)but-1-enyl)silane (1453868-77-3) → (E)-trimethyl(4-(tetrahydro-2H-pyran-2-yloxy)-1-(p-tolyl)but-1-enyl)silane (1453869-17-4)

Guidance literature:

With C₄₀H₇₂O₄P₂Ru; silver fluoride; potassium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 10h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ja405752w

Reference yield:

trimethyl(4-((tetrahydro-2H-pyran-2-yl)oxy)but-1-yn-1-yl)silane (69361-40-6) → (E)-trimethyl(4-(tetrahydro-2H-pyran-2-yloxy)-1-(p-tolyl)but-1-enyl)silane (1453869-17-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tris(acetonitrile)pentamethylcyclopentadienylruthenium(II) hexafluorophosphate / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: C₄₀H₇₂O₄P₂Ru; silver fluoride; potassium hydrogencarbonate / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

With tris(acetonitrile)pentamethylcyclopentadienylruthenium(II) hexafluorophosphate; C₄₀H₇₂O₄P₂Ru; silver fluoride; potassium hydrogencarbonate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja405752w

upstream raw materials:

4-tolyl iodide

(Z)-triethoxy(4-(tetrahydro-2H-pyran-2-yloxy)-1-(trimethylsilyl)but-1-enyl)silane

trimethyl(4-((tetrahydro-2H-pyran-2-yl)oxy)but-1-yn-1-yl)silane