diethyl α-bromophenylmalonate

Base Information

Chemical Name:diethyl α-bromophenylmalonate
CAS No.:69836-07-3
Molecular Formula:C₁₃H₁₅BrO₄
Molecular Weight:315.164
Hs Code.:

Synonyms:diethyl α-bromophenylmalonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl α-bromophenylmalonate

Chemical Property:

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Technology Process of diethyl α-bromophenylmalonate

There total 3 articles about diethyl α-bromophenylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 591-50-4
iodobenzene

: 685-87-0
Diethyl 2-bromomalonate

: 69836-07-3
diethyl α-bromophenylmalonate

Guidance literature:: Diethyl 2-bromomalonate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

iodobenzene; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jacs.1c12404

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 685-87-0
Diethyl 2-bromomalonate

: 69836-07-3
diethyl α-bromophenylmalonate

Guidance literature:: Diethyl 2-bromomalonate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

bromobenzene; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jacs.1c12404

Reference yield:

: 101-97-3
Ethyl 2-phenylethanoate

: 69836-07-3
diethyl α-bromophenylmalonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jacs.1c12404