(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((1SR,2RS)-2-m-tolylcyclopropylamino)ethoxy)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((1SR,2RS)-2-m-tolylcyclopropylamino)ethoxy)pyrrolidine-1-carboxylate
CAS No.:1237495-01-0
Molecular Formula:C₃₈H₅₆N₄O₇
Molecular Weight:680.885
Hs Code.:

(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((1SR,2RS)-2-m-tolylcyclopropylamino)ethoxy)pyrrolidine-1-carboxylate

Synonyms:(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((1SR,2RS)-2-m-tolylcyclopropylamino)ethoxy)pyrrolidine-1-carboxylate

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Chemical Property of (3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((1SR,2RS)-2-m-tolylcyclopropylamino)ethoxy)pyrrolidine-1-carboxylate

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Technology Process of (3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((1SR,2RS)-2-m-tolylcyclopropylamino)ethoxy)pyrrolidine-1-carboxylate

There total 7 articles about (3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((1SR,2RS)-2-m-tolylcyclopropylamino)ethoxy)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1237495-45-2
(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-oxoethoxy)pyrrolidine-1-carboxylate

: 220350-32-3
(1R,2S)-2-m-Tolyl-cyclopropylamine

: 1237495-01-0
(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((1SR,2RS)-2-m-tolylcyclopropylamino)ethoxy)pyrrolidine-1-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1237495-45-2
(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-oxoethoxy)pyrrolidine-1-carboxylate

: C₁₀H₁₃N*C₂HF₃O₂

: 1237495-01-0
(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((1S,2R/1R,2S)-2-(m-tolyl)cyclopropylamino)ethoxy)pyrrolidine-1-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2012.12.019

Reference yield:

: trans-2-(3-methylphenyl)cyclopropanecarboxylic acid

: 1237495-01-0
(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((1S,2R/1R,2S)-2-(m-tolyl)cyclopropylamino)ethoxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: diphenyl phosphoryl azide; triethylamine / 48 h / 85 °C

2: dichloromethane / 20 °C

3: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 3 h / 20 °C

With diphenyl phosphoryl azide; sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; 1: |Curtius Rearrangement;
DOI:10.1016/j.bmc.2012.12.019