6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocyclohepten-3-ol

Base Information

Chemical Name:6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocyclohepten-3-ol
CAS No.:113748-77-9
Molecular Formula:C₂₇H₂₉NO₂
Molecular Weight:399.533
Hs Code.:

Synonyms:6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocyclohepten-3-ol

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Chemical Property of 6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocyclohepten-3-ol

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Technology Process of 6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocyclohepten-3-ol

There total 7 articles about 6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocyclohepten-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 113748-83-7
3-methoxy-6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocycloheptene

: 113748-77-9
6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocyclohepten-3-ol

Guidance literature:: With pyridine hydrochloride; at 200 ℃; for 2h;
DOI:10.1021/jm00402a005

Reference yield:

: 28557-00-8
phenylzinc chloride

: 113748-77-9
6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocyclohepten-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / Pd(PPh₃)4 / diethyl ether; tetrahydrofuran; cyclohexane / 2 h / Heating

2: 96 percent / NaOMe / dimethylformamide / 2 h / 35 °C

3: 1.) NaH / 1) DMF, room temperature; 2) 60 deg C, DMF, 30 min

4: 80 percent / pyridine hydrochloride / 2 h / 200 °C

With sodium methylate; pyridine hydrochloride; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00402a005

Reference yield:

: 113748-80-4
3-methoxy-6,7-dihydro-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

: 113748-77-9
6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocyclohepten-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / pyridine hydrobromide perbromide / CH₂Cl₂ / 3 h

2: 96 percent / Pd(PPh₃)4 / diethyl ether; tetrahydrofuran; cyclohexane / 2 h / Heating

3: 96 percent / NaOMe / dimethylformamide / 2 h / 35 °C

4: 1.) NaH / 1) DMF, room temperature; 2) 60 deg C, DMF, 30 min

5: 80 percent / pyridine hydrochloride / 2 h / 200 °C

With sodium methylate; pyridine hydrochloride; pyridinium hydrobromide perbromide; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00402a005