(Z)-(2R)-5-(N-(Benzyloxycarbonyl)amino)-4-fluoro-2-(2-methylpropyl)-3-pentenoic acid

Base Information

• Chemical Name: (Z)-(2R)-5-(N-(Benzyloxycarbonyl)amino)-4-fluoro-2-(2-methylpropyl)-3-pentenoic acid
• CAS No.: 163810-37-5
• Molecular Formula: C₁₇H₂₂FNO₄
• Molecular Weight: 323.364

Synonyms:(Z)-(2R)-5-(N-(Benzyloxycarbonyl)amino)-4-fluoro-2-(2-methylpropyl)-3-pentenoic acid

Chemical Property of (Z)-(2R)-5-(N-(Benzyloxycarbonyl)amino)-4-fluoro-2-(2-methylpropyl)-3-pentenoic acid

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Technology Process of (Z)-(2R)-5-(N-(Benzyloxycarbonyl)amino)-4-fluoro-2-(2-methylpropyl)-3-pentenoic acid

There total 1 articles about (Z)-(2R)-5-(N-(Benzyloxycarbonyl)amino)-4-fluoro-2-(2-methylpropyl)-3-pentenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-(Benzyloxycarbonyl)-N-((Z)-(4R)-2-fluoro-4-(hydroxymethyl)-6-methyl-2-heptenyl)amine → (Z)-(2R)-5-(N-(Benzyloxycarbonyl)amino)-4-fluoro-2-(2-methylpropyl)-3-pentenoic acid (163810-37-5)

Guidance literature:

With jones reagent; In acetone; for 1h; Ambient temperature;

DOI:10.1021/jo00115a028

Reference yield: 89.0%

L-Alanine methyl ester (10065-72-2) + (Z)-(2R)-5-(N-(Benzyloxycarbonyl)amino)-4-fluoro-2-(2-methylpropyl)-3-pentenoic acid (163810-37-5) → N-((Z)-(2R)-5-(N-(Benzyloxycarbonyl)amino)-4-fluoro-2-(2-methylpropyl)-3-pentenoyl)-L-alanine methyl ester

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/jo00115a028

Reference yield: 87.0%

methoxycarbonylmethylamine (616-34-2) + (Z)-(2R)-5-(N-(Benzyloxycarbonyl)amino)-4-fluoro-2-(2-methylpropyl)-3-pentenoic acid (163810-37-5) → N-((Z)-(2R)-5-(N-(Benzyloxycarbonyl)amino)-4-fluoro-2-(2-methylpropyl)-3-pentenoyl)glycine methyl ester

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/jo00115a028

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