(S)-5-Ethoxy-6-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3-methyl-3,6-dihydro-1H-pyrazin-2-one

Base Information

• Chemical Name: (S)-5-Ethoxy-6-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3-methyl-3,6-dihydro-1H-pyrazin-2-one
• CAS No.: 215179-99-0
• Molecular Formula: C₁₅H₁₈N₂O₃
• Molecular Weight: 274.32
• Mol file: 215179-99-0.mol

Synonyms:(S)-5-Ethoxy-6-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3-methyl-3,6-dihydro-1H-pyrazin-2-one

Chemical Property of (S)-5-Ethoxy-6-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3-methyl-3,6-dihydro-1H-pyrazin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-5-Ethoxy-6-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3-methyl-3,6-dihydro-1H-pyrazin-2-one

There total 5 articles about (S)-5-Ethoxy-6-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3-methyl-3,6-dihydro-1H-pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

triethyloxonium fluoroborate (368-39-8) + (S,Z)-3-benzylidene-6-methylpiperazine-2,5-dione (215179-95-6) → (S)-5-Ethoxy-6-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3-methyl-3,6-dihydro-1H-pyrazin-2-one (215179-99-0)

Guidance literature:

With sodium carbonate; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(98)00744-3

Reference yield:

(N-(tert-butoxycarbonyl)-L-alaninyl)glycine ethyl ester (65671-83-2) → (S)-5-Ethoxy-6-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3-methyl-3,6-dihydro-1H-pyrazin-2-one (215179-99-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / 0.5 h / 200 °C

2: 99 percent / 7 h / 140 °C

3: 71 percent / potassium tert-butoxide / dimethylformamide; 2-methyl-propan-2-ol / 22 h / Ambient temperature

4: 92 percent / hydrazine hydrate / dimethylformamide / 3 h / Ambient temperature

5: 65 percent / Na₂CO₃ / CH₂Cl₂ / 24 h / Ambient temperature

With potassium tert-butylate; sodium carbonate; hydrazine hydrate; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/S0040-4020(98)00744-3

Reference yield:

(S)-3-methyl-2,5-piperazinedione (4526-77-6) → (S)-5-Ethoxy-6-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3-methyl-3,6-dihydro-1H-pyrazin-2-one (215179-99-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / 7 h / 140 °C

2: 71 percent / potassium tert-butoxide / dimethylformamide; 2-methyl-propan-2-ol / 22 h / Ambient temperature

3: 92 percent / hydrazine hydrate / dimethylformamide / 3 h / Ambient temperature

4: 65 percent / Na₂CO₃ / CH₂Cl₂ / 24 h / Ambient temperature

With potassium tert-butylate; sodium carbonate; hydrazine hydrate; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/S0040-4020(98)00744-3

upstream raw materials:

triethyloxonium fluoroborate

(S,Z)-3-benzylidene-6-methylpiperazine-2,5-dione

(N-(tert-butoxycarbonyl)-L-alaninyl)glycine ethyl ester

(S)-1-Acetyl-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-6-methyl-piperazine-2,5-dione

Downstream raw materials:

(S)-1-(2-Azido-benzoyl)-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-6-methyl-piperazine-2,5-dione