2,3,5,6-Tetrahydro-5-(m-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

Base Information

Chemical Name:2,3,5,6-Tetrahydro-5-(m-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol
CAS No.:84775-00-8
Molecular Formula:C₁₇H₁₅ClN₂O
Molecular Weight:298.772
Hs Code.:2933990090
DSSTox Substance ID:DTXSID201005065
Nikkaji Number:J61.470J
ChEMBL ID:CHEMBL164504
Mol file:84775-00-8.mol

Synonyms:84775-00-8;BRN 6226683;2,3,5,6-Tetrahydro-5-(m-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol;5-(3-Chlorophenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol;Imidazo(2,1-a)isoquinolin-5-ol, 2,3,5,6-tetrahydro-5-(m-chlorophenyl)-;CHEMBL164504;DTXSID201005065;LS-77907

Suppliers and Price of 2,3,5,6-Tetrahydro-5-(m-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2,3,5,6-TETRAHYDRO-5-(M-CHLOROPHENYL)-IMIDAZO(2,1-A)ISOQUINOLIN-5-OL 95.00%
5MG
$ 497.43

Total 3 raw suppliers

Chemical Property of 2,3,5,6-Tetrahydro-5-(m-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

Chemical Property:

Vapor Pressure:9.36E-10mmHg at 25°C
Boiling Point:473.1°C at 760 mmHg
Flash Point:239.9°C
PSA：35.83000
Density:1.35g/cm³
LogP:2.17710
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:298.0872908
Heavy Atom Count:21
Complexity:441

Purity/Quality:: 2,3,5,6-TETRAHYDRO-5-(M-CHLOROPHENYL)-IMIDAZO(2,1-A)ISOQUINOLIN-5-OL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN2C(=N1)C3=CC=CC=C3CC2(C4=CC(=CC=C4)Cl)O

Technology Process of 2,3,5,6-Tetrahydro-5-(m-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

There total 3 articles about 2,3,5,6-Tetrahydro-5-(m-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 618-46-2
m-Chlorobenzoyl chloride

: 84775-00-8
5-(3-Chloro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: Multi-step reaction with 2 steps

1: benzene; methanol / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h

With n-butyllithium; In methanol; benzene;
DOI:10.1021/jm00359a025

Reference yield:

: 535-80-8
3-chlorobenzoate

: 84775-00-8
5-(3-Chloro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂ / 5 h / Heating

2: benzene; methanol / Ambient temperature

3: 1.) n-BuLi / 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h

With n-butyllithium; thionyl chloride; In methanol; dichloromethane; benzene;
DOI:10.1021/jm00359a025

Reference yield:

: 2905-65-9
methyl 3-chlorobenzoate

: 57327-93-2
2-(o-Tolyl)-2-imidazoline

: 84775-00-8
5-(3-Chloro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h;
DOI:10.1021/jm00359a025