Technology Process of N2-(3,4-dimethyl-5-hydroxymethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine
There total 9 articles about N2-(3,4-dimethyl-5-hydroxymethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N2-(3-carboxy-4,5-dimethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine;
With
borane-THF;
In
tetrahydrofuran;
at 20 ℃;
for 72h;
With
hydrogenchloride; methanol;
In
tetrahydrofuran; 1,3-dioxane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: potassium nitrate; sulfuric acid / 0 - 20 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 2068.65 Torr
4.1: trifluoroacetic acid / isopropyl alcohol / 100 °C / Sealed tube
5.1: potassium hydroxide; water / tetrahydrofuran / 2 h / 60 °C
5.2: pH 6
6.1: borane-THF / tetrahydrofuran / 72 h / 20 °C
With
borane-THF; sulfuric acid; water; hydrogen; potassium carbonate; potassium nitrate; trifluoroacetic acid; potassium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium nitrate; sulfuric acid / 0 - 20 °C
2.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 2068.65 Torr
3.1: trifluoroacetic acid / isopropyl alcohol / 100 °C / Sealed tube
4.1: potassium hydroxide; water / tetrahydrofuran / 2 h / 60 °C
4.2: pH 6
5.1: borane-THF / tetrahydrofuran / 72 h / 20 °C
With
borane-THF; sulfuric acid; water; hydrogen; potassium nitrate; trifluoroacetic acid; potassium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; isopropyl alcohol;
