4-[6-methoxy-2-(4-fluorophenyl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl]phenol

Base Information

Chemical Name:4-[6-methoxy-2-(4-fluorophenyl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl]phenol
CAS No.:645393-89-1
Molecular Formula:C₂₃H₂₂FNO₂
Molecular Weight:363.432
Hs Code.:

Synonyms:4-[6-methoxy-2-(4-fluorophenyl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl]phenol

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Chemical Property of 4-[6-methoxy-2-(4-fluorophenyl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl]phenol

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Technology Process of 4-[6-methoxy-2-(4-fluorophenyl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl]phenol

There total 4 articles about 4-[6-methoxy-2-(4-fluorophenyl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 645389-40-8
1-(4-(benzyloxy)phenyl)-2-(4-fluorophenyl)-6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

: 645393-89-1
4-[6-methoxy-2-(4-fluorophenyl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl]phenol

Guidance literature:: 1-(4-(benzyloxy)phenyl)-2-(4-fluorophenyl)-6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline; With aluminum (III) chloride; N,N-dimethyl-aniline; In dichloromethane; at 20 ℃; for 2h;

With water; sodium hydrogencarbonate; In dichloromethane; pH=5;
DOI:10.1016/j.ejmech.2008.01.001

Reference yield:

: 1-(4-(benzyloxy)phenyl)-2-(4-fluorophenyl)-6-methoxy-3,4-dihydroisoquinolinium perchlorate

: 645393-89-1
4-[6-methoxy-2-(4-fluorophenyl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl]phenol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; diethyl ether / 0 - 20 °C

2: AlCl₃; Me₂NPh / CH₂Cl₂ / 20 °C

With aluminium trichloride; N,N-dimethyl-aniline; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm030086h

Reference yield:

: 645388-75-6
6-methoxy-2-(4-fluorophenyl)-3,4-dihydroisoquinolin-1(2H)-one

: 645393-89-1
4-[6-methoxy-2-(4-fluorophenyl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl]phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: hexane; tetrahydrofuran / -78 °C

1.2: aq. HClO₄ / hexane; tetrahydrofuran; ethyl acetate / 0.17 h

2.1: tetrahydrofuran; diethyl ether / 0 - 20 °C

3.1: AlCl₃; Me₂NPh / CH₂Cl₂ / 20 °C

With aluminium trichloride; N,N-dimethyl-aniline; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jm030086h